Document Detail


Nutritional and metabolic studies of distillable fractions from fresh and thermally oxidized corn oil and olive oil.
MedLine Citation:
PMID:  628315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A semisynthetic diet containing 15% by weight of dietary fat was fed to six groups of male wistar rats for 28 days. Two groups received the distillable fraction of fresh corn oil (DCO) or fresh olive oil (DOO), two groups the distallable fractions of the thermally oxidized fats (OCO,OOO), and two groups received the respective fresh fats as controls (FCO, FOO). Substantial changes in the fatty acid composition occurred in the fats upon thermal oxidation. Only the rats that received OOO showed overt symptoms of heated fat toxicity. This was reflected in the histological scores of these animals with the liver sustaining the most numerous and severe lesions. Tissue fatty acid changes of any significance were confined largely to the polar liver lipid of the rats that were fed OCO or OOO. The results of this study would suggest that the relatively greater toxicity of OOO, compared to OCO, may in part be due to the high oleic:linoleic acid ratio of the fresh olive oil and in part to a higher tocopherol content of the corn oil.
Authors:
H G Gabriel; J C Alexander; V E Valli
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lipids     Volume:  13     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / analysis
Animals
Dietary Fats / adverse effects*
Drug-Induced Liver Injury
Fatty Acids / analysis,  metabolism,  toxicity
Hot Temperature / adverse effects*
Male
Nutritional Requirements
Oils / metabolism,  toxicity*
Oxidation-Reduction
Rats
Zea mays
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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