Document Detail

Nutritional and metabolic status of HIV-positive patients with lipodystrophy during one year of follow-up.
MedLine Citation:
PMID:  21552663     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this prospective study was to compare changes in lipid metabolism and nutritional status after either 6 and 12 months of follow-up in subjects with lipodystrophy syndrome after traditional lifestyle therapy with or without fibric acid analogue intervention (bezafibrate and clofibrate).
METHODS: Food intake, alterations in body composition and metabolic abnormalities were assessed in subjects with lipodystrophy syndrome at the beginning of the study. The nutritional status and metabolic alterations of the subjects were monitored, and the subjects received nutritional counseling each time they were seen. The subjects were monitored either two times over a period no longer than six months (Group A; n = 18) or three times over a period of at least 12 months (Group B; n = 35). All of the subjects underwent nutrition counseling that was based on behavior modification. The fibric acid analogue was only given to patients with serum triglyceride levels above 400 mg/dL.
RESULTS: After six months of follow-up, Group A showed no alterations in the experimental parameters. After twelve months, there was a decrease in serum triglyceride levels (410.4 ± 235.5 vs. 307.7 ± 150.5 mg/dL, p < 0.05) and an increase in both HDLc levels (37.9 ± 36.6 vs. 44.9 ± 27.9 mg/dL, p,0.05) and lean mass (79.9 ± 7.8 vs. 80.3 ± 9.9 %, p < 0.05) in Group B.
CONCLUSION: After one year of follow-up (three sessions of nutritional and medical counseling), the metabolic parameters of the subjects with lipodystrophy improved after traditional lifestyle therapy with or without fibric acid analogue intervention.
Eloísa Marchi Dos Anjos; Karina Pfrimer; Alcyone Artioli Machado; Selma Freire de Carvalho Cunha; Roberta Garcia Salomão; Jacqueline Pontes Monteiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-09     Completed Date:  2011-11-10     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  407-10     Citation Subset:  IM    
Department of Pediatrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
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MeSH Terms
Antiretroviral Therapy, Highly Active
Cholesterol, HDL / metabolism
Fibric Acids / metabolism*
Follow-Up Studies
HIV-Associated Lipodystrophy Syndrome / metabolism*,  therapy
Hyperlipidemias / therapy
Life Style
Middle Aged
Nutritional Status*
Prospective Studies
Statistics, Nonparametric
Time Factors
Triglycerides / metabolism
Reg. No./Substance:
0/Cholesterol, HDL; 0/Fibric Acids; 0/Triglycerides

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