Document Detail

Nutritional intervention in acute diarrhea: is a lactose-free formula essential?
MedLine Citation:
PMID:  1439975     Owner:  NLM     Status:  MEDLINE    
A prospective study was done to determine the incidence of disaccharide intolerance among 3-36 month-old patients with acute watery diarrhea who were on breast feeding and/or lactose-containing formula. The effect of feeding intervention on the outcome was investigated. Significant disaccharide intolerance was defined as one with (1) biochemical derangements: stool pH < 6.0 (Riedel de Haen pH paper) and reducing substances > or = 0.5 mg% (Clinitest) on two consecutive determinations and (2) clinical evidence: high purging rate (> 10 gm/kg/hour) and reappearance of dehydration and/or weight loss while on a lactose containing milk. Seven of 92 patients (7.8%) had biochemical evidence of disaccharide malabsorption on admission. Subsequent monitoring of the study population showed absence of disaccharide intolerance. Despite a lactose containing formula, a significant (p < 0.05) reduction in stool output from the first to the second day (145.85 +/- 130.26 vs 115.43 +/- 95.65 g/kg admission weight) was noted. Likewise, weight gain from admission to discharge (4.56 +/- 3.44%) was observed. The mean total duration of illness (4.75 +/- 2.84 days) was well within the usual course of five to seven days. This study supports the current recommendation of continued breast feeding and/or use of lactose containing formula during acute watery diarrhea.
G V Gregorio; J M Rogacion; E P Gabriel; P D Santos Ocampo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  23     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-12-01     Completed Date:  1992-12-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  235-45     Citation Subset:  IM    
Department of Pediatrics, University of the Philippines, Philippine General Hospital, Ermita, Manila.
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MeSH Terms
Acute Disease
Breast Feeding*
Child, Preschool
Diarrhea / etiology,  physiopathology,  prevention & control*
Infant Food*
Lactose Intolerance / epidemiology*,  physiopathology
Prospective Studies
Weight Gain / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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