Document Detail

Nutritional intervention in COPD: a systematic overview.
MedLine Citation:
PMID:  11171709     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We conducted a systematic overview of randomized controlled trials (RCTs) to clarify the contribution of nutritional supplementation for patients with stable COPD. METHODS: RCTs were identified from several sources, including the Cochrane Airways Group register of RCTs, a hand search of abstracts presented at international meetings, and consultation with experts. Two reviewers independently selected trials for inclusion, assessed quality, and extracted the data. RESULTS: Twenty-one reports were classified according to the type, duration of supplementation, and the presence of anabolic substances. High carbohydrate meals were associated with an increase in carbon dioxide production and a decrease in exercise capacity. Short-term crossover studies in which diets of various compositions were administered supported the notion that high carbohydrate loads increase the stress on the ventilatory system. The influence of longer-term supplementation (> 2 weeks) on weight, anthropometry, and exercise capacity varied, without there being a consistent effect. Lean body weight was only occasionally reported and health-related quality of life too rarely to be included as an outcome. The influence of recombinant human growth hormone was disappointing. Anabolic steroids increased body weight and lean body mass, but had little influence on exercise capacity. CONCLUSION: This systematic overview in patients with COPD supports the notion that those with marginal ventilatory reserve might benefit from a dietary regimen in which a high percentage of calories are supplied by fat. Although there are reports of the benefits of nutritional repletion, trials of > 2 weeks failed to show consistent benefit on body weight. Evaluating nutritional repletion is hampered by the absence of information regarding body composition, exercise, and health-related quality of life. Growth hormone has not been shown to be useful. Further studies are needed to refine the beneficial effects of anabolic steroids as adjunctive agents together with nutritional support and exercise.
I Ferreira; D Brooks; Y Lacasse; R Goldstein
Related Documents :
21494899 - Relationship between mean body temperature calculated by two- or three-compartment mode...
16188909 - Decreased pdh activation and glycogenolysis during exercise following fat adaptation wi...
11427779 - Physical activity, total and regional obesity: dose-response considerations.
10648259 - Postprandial lipemia: effects of exercise and restriction of energy intake compared.
21655869 - Impaired functional and hemodynamic response to graded exercise testing and its recover...
21385519 - Using silver yoga exercises to promote physical and mental health of elders with dement...
22507359 - Exercise for rotator cuff tendinopathy: a systematic review.
258829 - A comparison of the oxygen consumption/body weight relationship obtained during submaxi...
12772019 - A pilot study of exercise training in adult patients with repaired tetralogy of fallot.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  119     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-63     Citation Subset:  AIM; IM    
Departments of Medicine, the University of Toronto and Respiratory Medicine, West Park Hospital, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anabolic Agents / therapeutic use
Body Composition
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Lung Diseases, Obstructive / diet therapy*
Nutritional Support*
Quality of Life
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Anabolic Agents; 0/Dietary Carbohydrates; 0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The costs of treating COPD in the United States.
Next Document:  Impact of a hospital-based home-care program on the management of COPD patients receiving long-term ...