Document Detail

Nutritional interpretation of folic acid interventions.
MedLine Citation:
PMID:  19335717     Owner:  NLM     Status:  MEDLINE    
Folate is an essential micronutrient, and its nutritional inadequacy is widespread; hence, programs to increase its intake are necessary. However, many concerns about possible adverse effects due to excesses have been raised. Serum folate levels are directly correlated with intake and, when low, are associated with neural tube defects (NTD), high blood homocysteine levels, and megaloblastic anemia. Serum folate cutoff points have been identified for each abnormality, and all can be associated with intakes related to the current recommended dietary parameters. Likewise, high intakes that overwhelm the physiological capacity to process folic acid into biologically active folate derivatives are near the recommended tolerable upper intake level. Although we do not know with certainty the minimum efficacious dose that prevents all folate-dependent NTD, it may actually be much lower than the current recommendation, especially when provided through food fortification; supplemental intakes around 100 microg/day appear to be appropriate.
Omar Dary
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  67     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-44     Citation Subset:  IM    
Academy for Educational Development, Washington, DC 20009-5721, USA.
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MeSH Terms
Folic Acid / administration & dosage*
Folic Acid Deficiency / prevention & control*
Food, Fortified
Homocysteine / drug effects
Neural Tube Defects / prevention & control*
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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