Document Detail

Nutritional intake of long-term survivors of childhood acute lymphoblastic leukemia: evidence for bone health interventional opportunities.
MedLine Citation:
PMID:  20981691     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Survivors of childhood acute lymphoblastic leukemia (ALL) are vulnerable to exaggeration of the aging process including decreased bone mineral density (BMD). As little is known about their dietary or nutrient intake that may affect their long-term bone health, we examined nutrient intake in long-term survivors of childhood ALL.
PROCEDURE: Survivors (n = 164) of childhood ALL who had completed treatment for at least 5 years and were in continuous remission, completed a 110-item food questionnaire that reflected dietary intake over the previous year. The analyzed cohort comprised 34 females and 38 males younger than 19 years and 45 females and 47 males at least 19 years. Reported nutrient intake and food selection were compared with age-specific Recommended Dietary Allowance and USDA Pyramid Food Guide. Body mass index was compared to the general US population, adjusted for age, gender, Tanner stage and race.
RESULTS: Less than 30% of participants met recommended dietary intakes for vitamin D, calcium, potassium, or magnesium regardless of age. Mean daily caloric intake was 2,204 kcal (51% from carbohydrates) for younger and 2,160 kcal (49% from carbohydrates) for older participants. Energy intake from sweets was 70% higher than recommended. Participants < 19 years were less likely to have a healthy weight (odds ratio 0.48, 95% CI 0.30-0.79); > 19 years more likely to be overweight (odds ratio 1.95, 95% CI 1.11-3.32, P < 0.002).
CONCLUSIONS: Survivors of childhood ALL need careful dietary intervention to optimize long-term health.
Frances A Tylavsky; Karen Smith; Harriet Surprise; Sarah Garland; Xiaowei Yan; Elizabeth McCammon; Melissa M Hudson; Ching-Hon Pui; Sue C Kaste
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  55     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-28     Completed Date:  2010-11-22     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1362-9     Citation Subset:  IM    
Department of Preventive Medicine, University of Tennessee, Health Science Center, Memphis, Tennessee, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Weight
Bone Density*
Calcium, Dietary / administration & dosage
Diet Records
Energy Intake
Nutrition Policy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
Vitamin D / administration & dosage
Young Adult
Grant Support
P30 CA-21765/CA/NCI NIH HHS; P30 CA021765/CA/NCI NIH HHS
Reg. No./Substance:
0/Calcium, Dietary; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Safety and efficacy of high dose intravenous desferrioxamine for reduction of iron overload in sickl...
Next Document:  Child-related determinants of health-related quality of life in children with brain tumours 1 year a...