Document Detail

Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice.
MedLine Citation:
PMID:  275859     Owner:  NLM     Status:  MEDLINE    
Striking inhibition of development of renal disease and prolongation of lifespan have been achieved in kdkd mice by restricting their daily food intake. Restricting protein intake alone did not prolong life nor did it inhibit development of kidney disease. The kdkd nephronophthisis, although very different histologically from the renal disease of B/W mice, may also have immunological components. Like the immunologically based renal disease of B/W mice, renal disease in kdkd mice is decreased or eliminated histologically by dietary restriction, which inhibits development of autoimmunity directed toward the erythrocytes of these mice. Further analysis will be needed to elucidate the cause of progressive renal disease in both the kdkd and B/W models and to permit understanding of the profound influence of restriction of food intake on development and progression of these very different renal diseases.
G Fernandes; E J Yunis; M Miranda; J Smith; R A Good
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  75     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2888-92     Citation Subset:  IM    
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MeSH Terms
Antibody Formation
Autoimmune Diseases / prevention & control*
Energy Intake
Kidney Diseases / genetics,  immunology,  pathology,  prevention & control*
Lymphocyte Activation
Spleen / immunology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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