Document Detail

Nutritional inadequacy in adults with muscular dystrophy.
MedLine Citation:
PMID:  15786416     Owner:  NLM     Status:  MEDLINE    
Patients with muscular dystrophy may be prone to nutrient deficiency due to mobility limitations or oropharyngeal weakness. Patients with myotonic muscular dystrophy (DM1) may be particularly prone to nutritional deficiencies from associated dysmotility of the entire gastrointestinal tract. We prospectively evaluated nutritional intake, body composition, and muscle strength in adult patients with DM1 (n = 29) and other muscular dystrophies (n = 22) on two occasions separated by approximately 6 months. Handgrip was significantly lower and knee extension higher for DM1 compared to other dystrophies, with no between-group differences in nutritional intakes. Many patients in both groups demonstrated inadequate nutrient intake of protein, energy, vitamins (water and fat soluble), and minerals (calcium and magnesium). Significant correlations were found between measures of strength and certain individual nutrients (e.g., copper and water-soluble vitamins). These data indicate that a substantial number of adults with muscular dystrophy do not meet current dietary intake recommendations. The potential clinical implications of these findings are discussed.
Bahareh Motlagh; Jay R MacDonald; Mark A Tarnopolsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Muscle & nerve     Volume:  31     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
Department of Medicine, Room 4U4, McMaster University, 1200 Main Street W., Hamilton, Ontario, L8N 3Z5, Canada.
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MeSH Terms
Avitaminosis / diagnosis,  physiopathology
Body Composition / physiology
Dietary Carbohydrates / metabolism
Dietary Proteins / metabolism
Energy Intake / physiology*
Exercise Tolerance / physiology
Malnutrition / diagnosis*,  etiology*,  physiopathology
Minerals / metabolism
Muscle Contraction / physiology
Muscle Weakness / diagnosis,  etiology*,  physiopathology
Myotonic Dystrophy / complications*,  physiopathology
Nutrition Policy
Prospective Studies
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Minerals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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