Document Detail


Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes.
MedLine Citation:
PMID:  18407743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic sensitivity to the bitter taste of phenylthiocarbamide and 6-n-propylthiouracil (PROP) is a well-studied human trait. It has been hypothesized that this phenotype is a marker for individual differences in taste perception that influence food preferences and dietary behavior with subsequent links to body weight and chronic disease risk. Steady progress has been made over the past several decades in defining the involvement of this phenotype and its underlying gene, TAS2R38, in this complex behavioral pathway. However, more work needs to be done to fully determine its overall nutritional and health significance. The primary goal of this review is to assess our current understanding of the role of the PROP bitter taste phenotype in food selection and body weight in both children and adults. A brief history of the field is included and controversies surrounding the use of different PROP screening methods are addressed. The contribution of other receptors (both bitter and nonbitter) to human taste variation is also discussed.
Authors:
Beverly J Tepper
Related Documents :
2602463 - Eating attitudes and taste responses in young ballerinas.
17406653 - Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens s...
2228413 - Obesity: a biogenetic or biobehavioral problem.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  28     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-10     Revised Date:  2008-12-29    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-88     Citation Subset:  IM    
Affiliation:
Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA. tepper@aesop.rutgers.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Body Weight / physiology*
Food Preferences / physiology*
Genetic Variation / genetics*
Humans
Propylthiouracil / diagnostic use
Taste / genetics*,  physiology*
Taste Threshold / genetics,  physiology
Tongue / physiology
Grant Support
ID/Acronym/Agency:
CA116766/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
51-52-5/Propylthiouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel chemotactic-antigen DNA vaccine against cancer.
Next Document:  The efficiency of cellular energy transduction and its implications for obesity.