Document Detail

Nutritional implications of genetic taste variation: the role of PROP sensitivity and other taste phenotypes.
MedLine Citation:
PMID:  18407743     Owner:  NLM     Status:  MEDLINE    
Genetic sensitivity to the bitter taste of phenylthiocarbamide and 6-n-propylthiouracil (PROP) is a well-studied human trait. It has been hypothesized that this phenotype is a marker for individual differences in taste perception that influence food preferences and dietary behavior with subsequent links to body weight and chronic disease risk. Steady progress has been made over the past several decades in defining the involvement of this phenotype and its underlying gene, TAS2R38, in this complex behavioral pathway. However, more work needs to be done to fully determine its overall nutritional and health significance. The primary goal of this review is to assess our current understanding of the role of the PROP bitter taste phenotype in food selection and body weight in both children and adults. A brief history of the field is included and controversies surrounding the use of different PROP screening methods are addressed. The contribution of other receptors (both bitter and nonbitter) to human taste variation is also discussed.
Beverly J Tepper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  28     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-10     Revised Date:  2008-12-29    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-88     Citation Subset:  IM    
Department of Food Science, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA.
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MeSH Terms
Body Weight / physiology*
Food Preferences / physiology*
Genetic Variation / genetics*
Propylthiouracil / diagnostic use
Taste / genetics*,  physiology*
Taste Threshold / genetics,  physiology
Tongue / physiology
Grant Support
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