Document Detail


Nutritional implications of cephalic phase gastrointestinal responses.
MedLine Citation:
PMID:  10744909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Palatable cephalic stimuli induce a simultaneous activation of gastrointestinal motility, gastric acid and pancreatic enzyme secretion, as well as, release of the gastrointestinal hormones gastrin and pancreatic polypeptide. Cholinergic neural input is the dominant mediator of these responses with cholecystokinin and gastrin acting as additional stimulatory modulators. Central cholinergic circuits, neuropeptide Y, and thyrotropin releasing hormone are candidate central stimulators of the cephalic phase. There are good arguments for glucagon-like peptide-1 and peptide YY to be physiological inhibitors of cephalic-phase responses with these peptides being released in the intestinal phase of digestion and putatively contributing to termination of the cephalically stimulated pattern. Cephalic-phase responses are used clinically as diagnostic tests to assess completeness of selective proximal vagotomy and to explore autonomic neuropathy. Pancreatic polypeptide secretion with sham feeding is an appropriate test of abdominal vagal function. Cephalically stimulated motor and secretory activity contribute greater than 50% of overall postprandial responses. Pharmacological inhibition of cephalic-vagal stimulation, resulting in reduced food intake, may be a novel approach to obesity management. Glucagon-like peptide-1 is a particular candidate because it inhibits the cephalic phase of digestion, diminishes food intake, and reduces the glycemic excursion after a meal by retarding gastric emptying, stimulating insulin and lowering glucagon release.
Authors:
M Katschinski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Appetite     Volume:  34     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  189-96     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Department of Gastroenterology and Endocrinology, Philipps-University Marburg, Baldingerstr. 1, Marburg, 35033, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Digestion
Digestive System Physiological Phenomena*
Eating / physiology*,  psychology
Gastric Acid / secretion
Gastrointestinal Hormones / physiology,  secretion
Hormone Antagonists / pharmacology
Humans
Motor Neurons / drug effects
Nutritional Physiological Phenomena
Parasympatholytics / pharmacology
Proglumide / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Hormone Antagonists; 0/Parasympatholytics; 107097-80-3/loxiglumide; 51-55-8/Atropine; 6620-60-6/Proglumide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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