Document Detail

Nutritional and functional importance of intestinal sulfur amino acid metabolism.
MedLine Citation:
PMID:  15987836     Owner:  NLM     Status:  MEDLINE    
The metabolism of sulfur amino acids, methionine and cysteine, has been linked to several key aspects of human health and cellular function. In addition, the metabolism of dietary amino acids by the gastrointestinal tract is nutritionally important for normal function. In the case of sulfur amino acids (SAAs), in vivo, stable isotope studies in adults suggest that the splanchnic tissues utilize as much as 30-44% of the dietary methionine and cysteine. Similarly, the dietary methionine requirement is 30% lower in total parenteral nutrition (TPN)-fed piglets, a condition in which dietary nutrients largely bypass intestinal metabolism. These data suggest that intestinal metabolism of methionine is substantial, yet the intestinal metabolic fate of dietary methionine is largely unknown. Dietary cysteine likely plays a key role in intestinal epithelial antioxidant function as a precursor for glutathione. Moreover, cysteine and glutathione may also regulate epithelial cell proliferation via modulation of redox status. Recent evidence indicates that transformed colonic epithelial cells are capable of methionine transmethylation and transsulfuration. This review discusses the evidence of intestinal SAA metabolism and how this affects nutrient requirements and epithelial function.
Anna K Shoveller; Barbara Stoll; Ronald O Ball; Douglas G Burrin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  135     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-30     Completed Date:  2005-08-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1609-12     Citation Subset:  IM    
Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada N1G 2W1.
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MeSH Terms
Amino Acids, Sulfur / metabolism*
Cysteine / metabolism
Intestinal Absorption
Methionine / metabolism
Models, Biological
Nutritional Physiological Phenomena*
Parenteral Nutrition, Total
Grant Support
Reg. No./Substance:
0/Amino Acids, Sulfur; 52-90-4/Cysteine; 63-68-3/Methionine

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