Document Detail

Nutritional factors in the pathogenesis and therapy of respiratory insufficiency in neuromuscular diseases.
MedLine Citation:
PMID:  8257975     Owner:  NLM     Status:  MEDLINE    
Malnutrition is a serious threat to patients with neuromuscular disease and marginally-compensated respiratory muscle weakness. It causes atrophy of inspiratory muscles, further weakening them. It reduces respiratory drive, potentially aggravating respiratory failure, either directly or indirectly, by promoting atelectasis and pneumonia, and it contributes strongly to such patients' risk of infection, their most common cause of death. In treating such patients, it must be remembered that abrupt increases in nutritional support, particularly with high percentages of carbohydrates, will increase CO2 production, potentially worsening ventilatory failure. Certain selected neuromuscular disease patients benefit from specific nutritional treatments (carnitine for carnitine deficient patients, high-calorie diets for muscular dystrophy and acid-maltase deficiency). Finally, the amino acid, fat, and nucleic acid content of the diet affects the immune response in beneficial or harmful ways, that are just now being elucidate. The potential for useful nutritional interventions in patients with neuromuscular diseases has never looked better, but is not yet fully realized. The challenges for the future will be to work out the beneficial and harmful effects of the various nutrients in the various diseases, to find ways to rapidly identify patients who will benefit, and to determine the safest, least uncomfortable, and most effective methods of delivery of the required nutrients.
T K Aldrich
Related Documents :
15750945 - The effect of growth hormone supplementation on late nutritional independence in pediat...
16420295 - Postinfectious gastroparesis related to autonomic failure: a case report.
3086585 - Metabolic derangements in children requiring parenteral nutrition.
815725 - Total parenteral nutrition.
7149085 - Ect in anxiety: an appraisal.
2682105 - Bacillaemia in leprosy and effect of multidrug therapy.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  48     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-01-14     Completed Date:  1994-01-14     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Albert Einstein College of Medicine, Montefiore Medical Center, New York 10467.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Neuromuscular Diseases / complications*
Nutrition Disorders / complications,  diet therapy*
Respiratory Insufficiency / etiology,  prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of ventilatory muscle training on respiratory function and capacity in ambulatory and bed...
Next Document:  Comprehensive rehabilitation of the severely disabled ventilator-assisted individual.