Document Detail


Nutritional factors in the pathogenesis and therapy of respiratory insufficiency in neuromuscular diseases.
MedLine Citation:
PMID:  8257975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malnutrition is a serious threat to patients with neuromuscular disease and marginally-compensated respiratory muscle weakness. It causes atrophy of inspiratory muscles, further weakening them. It reduces respiratory drive, potentially aggravating respiratory failure, either directly or indirectly, by promoting atelectasis and pneumonia, and it contributes strongly to such patients' risk of infection, their most common cause of death. In treating such patients, it must be remembered that abrupt increases in nutritional support, particularly with high percentages of carbohydrates, will increase CO2 production, potentially worsening ventilatory failure. Certain selected neuromuscular disease patients benefit from specific nutritional treatments (carnitine for carnitine deficient patients, high-calorie diets for muscular dystrophy and acid-maltase deficiency). Finally, the amino acid, fat, and nucleic acid content of the diet affects the immune response in beneficial or harmful ways, that are just now being elucidate. The potential for useful nutritional interventions in patients with neuromuscular diseases has never looked better, but is not yet fully realized. The challenges for the future will be to work out the beneficial and harmful effects of the various nutrients in the various diseases, to find ways to rapidly identify patients who will benefit, and to determine the safest, least uncomfortable, and most effective methods of delivery of the required nutrients.
Authors:
T K Aldrich
Related Documents :
6441765 - Lithium and lecithin treatment in alzheimer's disease: a pilot study.
9892375 - Dietary protein and energy requirements in esrd patients.
2138545 - Thiamine tetraphydrofurfuryl disulfide in nutritional polyneuropathy.
14697975 - Prevalence of liver complications in pediatric patients on home parenteral nutrition: i...
23236325 - Fenofibrate reduces c-reactive protein levels in hypertriglyceridemic patients with hig...
21167145 - Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a ca...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  48     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-01-14     Completed Date:  1994-01-14     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
Affiliation:
Albert Einstein College of Medicine, Montefiore Medical Center, New York 10467.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Humans
Neuromuscular Diseases / complications*
Nutrition Disorders / complications,  diet therapy*
Respiratory Insufficiency / etiology,  prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of ventilatory muscle training on respiratory function and capacity in ambulatory and bed...
Next Document:  Comprehensive rehabilitation of the severely disabled ventilator-assisted individual.