| Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. | |
| | |
MedLine Citation:
|
PMID: 19748594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The discovery of the nitric oxide (NO) pathway in the 1980s represented a critical advance in understanding cardiovascular disease, and today a number of human diseases are characterized by NO insufficiency. In the interim, recent biomedical research has demonstrated that NO can be modulated by the diet independent of its enzymatic synthesis from l-arginine, e.g., the consumption of nitrite- and nitrate-rich foods such as fruits, leafy vegetables, and cured meats along with antioxidants. Regular intake of nitrate-containing food such as green leafy vegetables may ensure that blood and tissue levels of nitrite and NO pools are maintained at a level sufficient to compensate for any disturbances in endogenous NO synthesis. However, some in the public perceive that dietary sources of nitrite and nitrate are harmful, and some epidemiological studies reveal a weak association between foods that contain nitrite and nitrate, namely cured and processed meats, and cancer. This paradigm needs revisiting in the face of undisputed health benefits of nitrite- and nitrate-enriched diets. This review will address and interpret the epidemiological data and discuss the risk-benefit evaluation of dietary nitrite and nitrate in the context of nitric oxide biology. The weak and inconclusive data on the cancer risk of nitrite, nitrate and processed meats are far outweighed by the health benefits of restoring NO homeostasis via dietary nitrite and nitrate. This risk/benefit balance should be a strong consideration before there are any suggestions for new regulatory or public health guidelines for dietary nitrite and nitrate exposures. |
| | |
Authors:
|
Andrew Milkowski; Harsha K Garg; James R Coughlin; Nathan S Bryan |
Related Documents
:
|
1378534 - Mutagenic potency of heterocyclic amines towards salmonella typhimurium; possible cause... 1904414 - Induction of intestinal adenocarcinomas by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyrid... 15036004 - Estimates of heterocyclic amine intake in the us population. 23256844 - Protein sequestration of lipophilic furanocoumarins in grapefruit juice. 12284004 - Curing water scarcity blindness. 21723894 - Consumers' attitudes toward consumption of cloned beef. the impact of exposure to techn... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-09-11 |
Journal Detail:
|
Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Volume: 22 ISSN: 1089-8611 ISO Abbreviation: Nitric Oxide Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-09 Completed Date: 2010-04-26 Revised Date: 2010-07-16 |
Medline Journal Info:
|
Nlm Unique ID: 9709307 Medline TA: Nitric Oxide Country: United States |
Other Details:
|
Languages: eng Pagination: 110-9 Citation Subset: IM |
Copyright Information:
|
(c) 2009 Elsevier Inc. All rights reserved. |
Affiliation:
|
Muscle Biology Laboratory, Department of Animal Sciences, University of Wisconsin, Madison, WI, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiovascular Diseases / drug therapy, epidemiology*, metabolism Diet* Humans Neoplasms / drug therapy, epidemiology*, metabolism Nitrates / administration & dosage* Nitric Oxide / metabolism* Nitrites / administration & dosage* Nutritional Physiological Phenomena* Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
|
Nitric Oxide. 2010 Sep 15;23(2):150-1
[PMID:
20452451
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Pharmacokinetic Study of Plerixafor in Subjects with Varying Degrees of Renal Impairment.
Next Document: Fasting suppresses T cell-mediated immunity in female Mongolian gerbils (Meriones unguiculatus).