Document Detail

Nutritional effects of feeding a ketoanalogue mixture in growing and adult uremic rats.
MedLine Citation:
PMID:  1442653     Owner:  NLM     Status:  MEDLINE    
Insufficient protein diets supplemented with ketoanalogue/essential amino acid (KA/EAA) mixtures are proposed to maintain nutrition and to retard renal deterioration. We compared in growing and in adult uremic rats diets containing limited or usual amounts of protein (12%, 20% for growing rats, and 10% and 16% for adult rats) with diets containing 50% or 60% less casein plus a KA/EAA mixture providing KA at an equimolar amount of removed EAA or at higher amounts. The latter supplement caused stunting, the former caused no anorexia, a slight growth deficit when added to the lowest basal casein diets, and almost normal growth when added to higher casein diets. Growth was normal with EAA supplements. The plasma EAA changes were unrelated to intake and to growth. Thus, KA utilization is maximal, provided that basal protein is sufficient and KA are not in excess.
S Maniar; D Laouari; M Burtin; P R Parvy; C Kleinknecht
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  56     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-18     Completed Date:  1992-12-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1025-33     Citation Subset:  AIM; IM    
INSERM U 192, Hôpital Necker-Enfants Malades, Paris, France.
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MeSH Terms
Amino Acids, Branched-Chain / blood
Amino Acids, Essential / administration & dosage,  blood,  therapeutic use*
Animal Nutritional Physiological Phenomena*
Dietary Proteins / administration & dosage
Keto Acids / administration & dosage,  therapeutic use*
Nitrogen / metabolism
Rats, Sprague-Dawley
Urea / blood
Uremia / diet therapy*
Weight Gain
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Amino Acids, Essential; 0/Dietary Proteins; 0/Keto Acids; 57-13-6/Urea; 7727-37-9/Nitrogen

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