| Nutritional effects of feeding a ketoanalogue mixture in growing and adult uremic rats. | |
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MedLine Citation:
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PMID: 1442653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insufficient protein diets supplemented with ketoanalogue/essential amino acid (KA/EAA) mixtures are proposed to maintain nutrition and to retard renal deterioration. We compared in growing and in adult uremic rats diets containing limited or usual amounts of protein (12%, 20% for growing rats, and 10% and 16% for adult rats) with diets containing 50% or 60% less casein plus a KA/EAA mixture providing KA at an equimolar amount of removed EAA or at higher amounts. The latter supplement caused stunting, the former caused no anorexia, a slight growth deficit when added to the lowest basal casein diets, and almost normal growth when added to higher casein diets. Growth was normal with EAA supplements. The plasma EAA changes were unrelated to intake and to growth. Thus, KA utilization is maximal, provided that basal protein is sufficient and KA are not in excess. |
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Authors:
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S Maniar; D Laouari; M Burtin; P R Parvy; C Kleinknecht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 56 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1992-12-18 Completed Date: 1992-12-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1025-33 Citation Subset: AIM; IM |
Affiliation:
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INSERM U 192, Hôpital Necker-Enfants Malades, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Branched-Chain
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blood Amino Acids, Essential / administration & dosage, blood, therapeutic use* Animal Nutritional Physiological Phenomena* Animals Diet* Dietary Proteins / administration & dosage Eating Keto Acids / administration & dosage, therapeutic use* Male Nitrogen / metabolism Rats Rats, Sprague-Dawley Urea / blood Uremia / diet therapy* Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Branched-Chain; 0/Amino Acids, Essential; 0/Dietary Proteins; 0/Keto Acids; 57-13-6/Urea; 7727-37-9/Nitrogen |
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