Document Detail

Nutritional effects on auditory brainstem maturation in healthy term infants.
MedLine Citation:
PMID:  14977907     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effects of dietary long chain polyunsaturated fatty acid (LCPUFA) supplementation on auditory brainstem maturation of healthy term newborns during the first 16 weeks of life by measuring brainstem auditory evoked potentials (BAEPs). DESIGN: Throughout the 16 week study period, infants in the formula A group (n = 28) were assigned to be fed exclusively with the same formula supplemented with DHA, and infants in the formula B group (n = 26) were assigned to receive only a DHA unsupplemented but otherwise similar formula. During the study period, the first 26 consecutive infants to be fed exclusively on their mother's milk for at least the first 16 weeks of life were chosen as the control group. BAEP measurements were performed twice: at the first and 16th week of age. RESULTS: There were no significant differences among the study and control groups in the BAEP measurements performed at the study entry. At 16 weeks of age, all absolute wave and interpeak latencies in the study and control groups had significantly decreased. The decreases were significantly greater in the formula A and control groups than in the formula B group. CONCLUSIONS: Infants fed on human milk or a formula supplemented with LCPUFAs during the first 16 weeks of life show more rapid BAEP maturation than infants fed on a standard formula. Although the clinical importance and long term effects of these findings remain to be determined, routine supplementation of formulas with LCPUFAs should be considered.
B Unay; S U Sarici; U H Ulaş; R Akin; F Alpay; E Gökçay
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  89     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-23     Completed Date:  2004-04-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F177-9     Citation Subset:  AIM; IM    
Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
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MeSH Terms
Bottle Feeding
Brain Stem / growth & development*
Breast Feeding
Case-Control Studies
Child Development / physiology*
Dietary Fats, Unsaturated / administration & dosage
Double-Blind Method
Evoked Potentials, Auditory, Brain Stem / physiology
Infant Nutritional Physiological Phenomena*
Infant, Newborn / growth & development*
Reg. No./Substance:
0/Dietary Fats, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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