Document Detail

Nutritional and developmental regulation of glycosylation processes in digestive organs.
MedLine Citation:
PMID:  1576205     Owner:  NLM     Status:  MEDLINE    
We review the nutritional and developmental variations of the glycosylation processes in digestive organs, since glycoproteins play a prominent part as mucins or digestive enzymes in these tissues. The biosynthesis of the glycannic chains is demonstrated to be largely sensitive to various exogenous (such as nutritional) or endogenous (such as developmental) factors. Although the metabolic regulation by dietary variations appears as rather complex, according to the variety of experimental conditions and the diversity of the organs studied, available data demonstrate that this regulation does exist, depending on the quantity or sometimes the quality of the major or minor components of the diet, which induce significant variations in the glycosylation processes. The synthesis of the internal core of N-glycans is essentially regulated by diet-induced variations of the phosphoryl-dolichol level, whereas the modulation of the biosynthesis of the external part of N-glycans or the biosynthesis of O-glycans is controlled by diet-induced variations in the systems transferring fucose, galactose, sialic acid or hexosamines. Modifications in intestinal glycosylation during post-natal development in the rat control the quality of the glycannic chains of mucins and brush-border enzymes. The post-natal maturation of the intestinal rat tissue is characterized by a shift from sialylation to fucosylation, depending on coordinate changes in glycosyltransferase activities, in sugar-nucleotide breakdown or synthesis or in the activity of regulatory proteins. These activities are largely sensitive to dietary manipulations at weaning and to hormonal stimulations before weaning. However, glucocorticoid hormones do not appear as the triggering signal for the induction of these changes.
M C Biol; A Martin; P Louisot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimie     Volume:  74     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-06-08     Completed Date:  1992-06-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  13-24     Citation Subset:  IM    
Department of General and Medical Biochemistry, INSERM-CNRS U 189, Faculté de Médecine Lyon-Sud, Oullins, France.
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MeSH Terms
Digestive System / metabolism*
Glycoproteins / biosynthesis*
Nutritional Physiological Phenomena
Reg. No./Substance:

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