Document Detail


Nutritional determinants of epithelial ovarian cancer risk: a case-control study in Mexico.
MedLine Citation:
PMID:  12239450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Variations in the incidence of cancer can be influenced by diet and specific lifestyles. In the last years, diet has been evaluated as an important factor in the development of ovarian cancer, even though the results have not been consistent. Dietary factors related to the risk of ovarian cancer in Mexican women were evaluated. METHODS: A case-control study in Mexico City was done during 1995-1997 in a social security hospital, evaluating 84 new cases of ovarian cancer and 629 controls. A validated questionnaire with 116 items about the frequency and type of food intake was used. The analysis of nutrients was done with the residual method adjusted for total energy intake and other predictor variables through logistic regression methods. Also, partition models estimated the total caloric intake for other sources. RESULTS: The nutrients negatively associated with ovarian cancer in the highest versus the lowest tertile were retinol (OR 0.52; p for trend = 0.03) and vitamin D (OR 0.43; 95% CI 0.23-0.80; p = 0.01; residual model). Additionally, carbohydrates were positively associated (partition model: OR 1.08; 95% CI 1.00-1.15), and tortilla intake did not show an association with ovarian cancer (OR 0.96; 95% CI 0.78-1.17). CONCLUSIONS: The diet of the Mexican population is rich in carbohydrates; in Mexico corn intake is the main energy source. On the other hand, vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate our results. This is the first attempt in our country that relates the Mexican diet to ovarian cancer.
Authors:
Eduardo Salazar-Martinez; Eduardo C Lazcano-Ponce; Guillermo Gonzalez Lira-Lira; Pedro Escudero-De los Rios; Mauricio Hernandez-Avila
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Oncology     Volume:  63     ISSN:  0030-2414     ISO Abbreviation:  Oncology     Publication Date:  2002  
Date Detail:
Created Date:  2002-09-19     Completed Date:  2002-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Mexico. esalazar@correo.insp.mx
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Case-Control Studies
Dietary Carbohydrates / adverse effects
Dietary Fats
Dietary Fats, Unsaturated
Dietary Proteins
Energy Intake
Female
Fruit
Humans
Incidence
Meat
Mexico / epidemiology
Middle Aged
Nutritional Physiological Phenomena*
Ovarian Neoplasms / epidemiology*
Questionnaires
Risk Factors*
Vegetables
Vitamin A
Vitamin D
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Dietary Proteins; 11103-57-4/Vitamin A; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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