| Nutritional and clinical relevance of lutein in human health. | |
| | |
MedLine Citation:
|
PMID: 14513828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lutein is one of the most widely found carotenoids distributed in fruits and vegetables frequently consumed. Its presence in human tissues is entirely of dietary origin. Distribution of lutein among tissues is similar to other carotenoids but, along with zeaxanthin, they are found selectively at the centre of the retina, being usually referred to as macular pigments. Lutein has no provitamin A activity in man but it displays biological activities that have attracted great attention in relation to human health. Epidemiological studies have shown inconsistent associations between high intake or serum levels of lutein and lower risk for developing cardiovascular disease, several types of cancer, cataracts and age-related maculopathy. Also, lutein supplementation has provided both null and positive results on different biomarkers of oxidative stress although it is effective in increasing macular pigment concentration and in improving visual function in some, but not all, subjects with different eye pathologies. Overall, data suggest that whereas serum levels of lutein have, at present, no predictive, diagnostic or prognostic value in clinical practice, its determination may be very helpful in assessing compliance and efficacy of intervention as well as potential toxicity. In addition, available evidence suggests that a serum lutein concentration between 0.6 and 1.05 micromol/l seems to be a safe, dietary achievable and desirable target potentially associated with beneficial impact on visual function and, possibly, on the development of other chronic diseases. The use of lutein as a biomarker of exposure in clinical practice may provide some rationale for assessing its relationship with human health as well as its potential use within the context of evidence-based medicine. |
| | |
Authors:
|
F Granado; B Olmedilla; I Blanco |
Related Documents
:
|
12680988 - Humanism and the suffering of the people. 19568888 - Selenium: its role as antioxidant in human health. 15115348 - Home study program. can we build a safer or? 10381828 - Health and the environment: a human rights agenda for the future. 7106948 - Rda and related tracking systems concerned with sodium. 16001208 - Predictors of changes in sick leave in workers with asthma: a follow-up study. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: The British journal of nutrition Volume: 90 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-09-26 Completed Date: 2003-10-16 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 487-502 Citation Subset: IM |
Affiliation:
|
Servicio de Endocrinología y Nutricíon, Hospital Universitario Puerta de Hierro, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Availability Biological Markers / blood Cardiovascular Diseases / prevention & control Cataract / prevention & control Diet* Dietary Supplements Fruit Humans Lutein / blood*, metabolism Macular Degeneration / prevention & control Neoplasms / prevention & control Nutritional Physiological Phenomena* Retina / metabolism Vegetables Xanthophylls beta Carotene / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Xanthophylls; 127-40-2/Lutein; 144-68-3/zeaxanthin; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Medicare and Medicaid programs; requirements for paid feeding assistants in long term care facilitie...
Next Document: Heterologous expression of G-protein-coupled receptors: comparison of expression systems from the st...