Document Detail


Nutritional assessment and fate of DNA of soybean meal from roundup ready or conventional soybeans using rats.
MedLine Citation:
PMID:  15570744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to compare the safety of soybean meal prepared from genetically modified (GM) glyphosate-tolerant (Roundup Ready; RR) soybeans and conventional soybeans. Eighty Sprague-Dawley rats (40 males and 40 females) were randomly allotted to one of four groups according to sex and body weight for a 13-week feeding experiment. The rats were fed corn-based diets containing 60% conventional soybean meal, a mixture of 30% conventional and 30% RR soybean meal, 60% or 90% RR soybean meal. All diets were adjusted to an identical nutrient level except the 90% RR diet. The two soybean meals were similar in chemical analysis and amino acid composition. During the 13-week growth trial, body weight (P < 0.05) and feed intake (P < 0.05) decreased only in rats fed with 90% RR soybean meal at the first week. No treatment-related deaths occurred during the experiment. Gross necropsy findings, haematological or urinalysis values and clinical serum parameters showed no meaningful differences between rats fed the control and RR soybean meals. A 145 bp of cp4 epsps gene specific for the GM constructs from RR soybean meal or a 407 bp of lec gene from endogenous soybean DNA could not be detected in investigated masseter muscle samples. No adverse effects of glyphosate-tolerant soybean meal on rats were seen even at levels as high as 90% of the diet.
Authors:
Yuanzhao Zhu; Defa Li; Fenglai Wang; Jingdong Yin; Hong Jin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of animal nutrition     Volume:  58     ISSN:  1745-039X     ISO Abbreviation:  -     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-12-01     Completed Date:  2005-01-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101222433     Medline TA:  Arch Anim Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-310     Citation Subset:  IM    
Affiliation:
National Feed Engineering Technology Research Center, China Agricultural University, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animal Nutritional Physiological Phenomena*
Animals
Blood Chemical Analysis / veterinary
DNA, Plant / analysis*,  blood,  urine
Dose-Response Relationship, Drug
Energy Intake / drug effects
Female
Male
Nutrition Assessment
Plants, Genetically Modified* / adverse effects
Random Allocation
Rats
Rats, Sprague-Dawley / growth & development*
Safety
Soybean Proteins / administration & dosage*,  genetics
Soybeans / genetics*
Urinalysis / veterinary
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/DNA, Plant; 0/Soybean Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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