Document Detail

Nutritional aspects of manganese homeostasis.
MedLine Citation:
PMID:  16099026     Owner:  NLM     Status:  MEDLINE    
Manganese (Mn) is an essential mineral. It is present in virtually all diets at low concentrations. The principal route of intake for Mn is via food consumption, but in occupational cohorts, inhalation exposure may also occur (this subject will not be dealt with in this review). Humans maintain stable tissue levels of Mn. This is achieved via tight homeostatic control of both absorption and excretion. Nevertheless, it is well established that exposure to high oral, parenteral or ambient air concentrations of Mn can result in elevations in tissue Mn levels. Excessive Mn accumulation in the central nervous system (CNS) is an established clinical entity, referred to as manganism. It resembles idiopathic Parkinson's disease (IPD) in its clinical features, resulting in adverse neurological effects both in laboratory animals and humans. This review focuses on an area that to date has received little consideration, namely the potential exposure of parenterally fed neonates to exceedingly high Mn concentrations in parenteral nutrition solutions, potentially increasing their risk for Mn-induced adverse health sequelae. The review will consider (1) the essentiality of Mn; (2) the concentration ranges, means and variation of Mn in various foods and infant formulas; (3) the absorption, distribution, and elimination of Mn after oral exposure and (4) the factors that raise a theoretical concern that neonates receiving total parenteral nutrition (TPN) are exposed to excessive dietary Mn.
Judy L Aschner; Michael Aschner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  26     ISSN:  0098-2997     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:    2005 Aug-Oct
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-62     Citation Subset:  IM    
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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MeSH Terms
Infant Formula / chemistry
Manganese / metabolism*
Nutritional Physiological Phenomena*
Parenteral Nutrition, Total
Grant Support
Reg. No./Substance:

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