Document Detail


Nutritional aspects of dissimilatory sulfate reduction in the human large intestine.
MedLine Citation:
PMID:  9462959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In contrast to other anaerobic ecosystems, such as marine and estuarine sediments, there is a lack of information on the nutritional requirements of human gut sulfate-reducing bacteria (SRB). Various substrates stimulated sulfate reduction in mixed culture, including short-chain fatty acids and other organic acids, alcohols, and amino acids (but not sugars or aromatic compounds). However, the use of sodium molybdate as a specific inhibitor of sulfate reduction caused an accumulation of ethanol and malonate only, and reduced the rate of utilization of lactate. This indicates the importance of these electron donors for sulfate reduction. Since ethanol and lactate are primarily utilized by members of the Desulfovibrio genus, the results suggest a physiologically important role for this group. Experiments with two strains of Desulfovibrio desulfuricans isolated from human feces demonstrated that both were able to reduce sulfite, thiosulfate or nitrate in the absence of sulfate. In addition, one strain (DsvUC1) was able to grow by fermentative metabolism, although the second strain (DsvFD1) showed more restricted fermentative growth. The data indicate that desulfovibrios are ecologically the most significant group of SRB in the human colon, and that colonic isolates belonging to this genus are versatile, in terms of both the electron acceptors and donors that they are able to utilize.
Authors:
C L Willis; J H Cummings; G Neale; G R Gibson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current microbiology     Volume:  35     ISSN:  0343-8651     ISO Abbreviation:  Curr. Microbiol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-10     Completed Date:  1998-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7808448     Medline TA:  Curr Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  294-8     Citation Subset:  B    
Affiliation:
Institute of Food Research, Earley Gate, Reading, UK.
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MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism
Adult
Colon / microbiology*
Culture Media / metabolism
Desulfovibrio / growth & development,  isolation & purification,  metabolism*
Ethanol / metabolism
Feces / microbiology
Female
Fermentation
Humans
Lactic Acid / metabolism
Male
Malonates / metabolism
Molybdenum / metabolism
Nitrates / metabolism
Nitrites / metabolism
Sulfates / metabolism
Sulfites / metabolism
Thiosulfates / metabolism
Chemical
Reg. No./Substance:
0/Acetates; 0/Culture Media; 0/Malonates; 0/Nitrates; 0/Nitrites; 0/Sulfates; 0/Sulfites; 0/Thiosulfates; 141-82-2/malonic acid; 14259-85-9/molybdate; 50-21-5/Lactic Acid; 64-17-5/Ethanol; 7439-98-7/Molybdenum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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