| Nutritional approach to restore impaired intestinal barrier function and growth after neonatal stress in rats. | |
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MedLine Citation:
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PMID: 16819372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Psychological stress during the neonatal period results in intestinal barrier dysfunction and growth alterations later in life. We aimed to restore impaired barrier function and growth rate by a nutritional intervention. METHODS: Male rat pups (n = 84) were assigned to 1 of 2 rearing conditions from postnatal day (PND) 2 to PND14: S, separated 3 h/d from their mothers, or H, 15 min/d handled controls. From PND15 to PND35, rats received a control diet or a similar diet adapted to contain arachidonic and docosahexaenoic acids, galacto- and fructo-oligosaccharides and Lactobacillus paracasei NCC2461. RESULTS: Maternal separation had only a minor impact on the measured gut barrier parameters at PND15, whereas it severely affected them at PND35. At this age, intestinal permeability to macromolecules was higher, mucin content in small intestinal tissues was lower and microbiota composition was altered in S compared with H animals. Feeding the adapted diet normalized the intestinal permeability, although it did not restore intestinal mucin content or microbiota. In addition, the adapted diet improved the growth rate recovery of the S animals after weaning and resulted in increased villus length in small intestine. CONCLUSION: Our results suggest that an adapted diet containing specific long-chain polyunsaturated fatty acids, prebiotics and probiotics can revert the negative imprinting of neonatal stress on both intestinal barrier function and growth. |
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Authors:
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Clara L García-Ródenas; Gabriela E Bergonzelli; Sophie Nutten; Alexandra Schumann; Christine Cherbut; Marco Turini; Kurt Ornstein; Florence Rochat; Irène Corthésy-Theulaz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 43 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-04 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 16-24 Citation Subset: IM |
Affiliation:
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Nutrition and Health Department, Nestlé Research Center, Lausanne, Switzerland. clara.garcia@rdls.nestle.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Arachidonic Acid / administration & dosage, metabolism Body Weight Disease Models, Animal Docosahexaenoic Acids / administration & dosage, metabolism Eating Food, Formulated* Homeostasis Intestinal Absorption Intestinal Mucosa / growth & development*, metabolism, microbiology, physiopathology* Intestine, Small / growth & development*, metabolism, microbiology, physiopathology* Lactobacillus / metabolism Male Maternal Deprivation Mucins / metabolism Oligosaccharides / administration & dosage, metabolism Permeability Probiotics / administration & dosage, metabolism Rats Rats, Long-Evans Stress, Psychological / metabolism, microbiology, physiopathology* Time Factors Weaning |
| Chemical | |
Reg. No./Substance:
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0/Mucins; 0/Oligosaccharides; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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