| Nutritional application and implication of 1,3-butanediol. | |
| | |
MedLine Citation:
|
PMID: 1102338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Research in the United States on synthetic sources of dietary calories was initiated in 1958 to develop high nutrient density food for extended manned space travel. Of many known compounds screened, 1,3-butanediol was the most promising. Small amounts in ester form with fatty acids exist in nature, and tests indicate a low acute oral and chronic toxicity similar to that of propylene glycol or glycerol. Multi-generation reproduction, teratological, and mutagen studies have revealed nothing detrimental. Following an adaptation period, 1,3-butanediol furnishes approximately 6 kcal/g if fed at levels not exceeding 20% in the diet of rats. Higher levels result in an impairment in growth and food utilization. In young animals, body fat stores appear to be lessened, as is resistance to the stress of extreme cold. However, dogs fed 20% 1,3-butanediol can maintain sustained muscular work on treadmills, but larger amounts can result in incoordination due to a narcotic effect common to glycols. Little research has been conducted on the behavioral effects of large doses. At present, 1,3-butanediol is used mainly as a solvent for food flavors. If the unpleasant taste problem can be overcome and if given FDA approval, 1,3-butanediol may have an increased role in our food supply as a functional food additive, preservative, and source of calories for man and animals. |
| | |
Authors:
|
H A Dymsza |
Related Documents
:
|
14608808 - Regulatory considerations in the united states. 21802478 - Ochratoxin a in adult population of lleida, spain: presence in blood plasma and consump... 21199248 - Stepping in elton's footprints: a general scaling model for body masses and trophic lev... 6998888 - Effects of culture: geographical and historical approaches. 11902928 - Flavor and texture of banana chips dried by combinations of hot air, vacuum, and microw... 16049698 - Increase in dance imprecision with decreasing foraging distance in the honey bee apis m... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Federation proceedings Volume: 34 ISSN: 0014-9446 ISO Abbreviation: Fed. Proc. Publication Date: 1975 Nov |
Date Detail:
|
Created Date: 1976-01-14 Completed Date: 1976-01-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372771 Medline TA: Fed Proc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2167-70 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Butylene Glycols / metabolism*, pharmacology, toxicity Central Nervous System / drug effects, physiology Diet Dogs Food Additives / metabolism* Food Preservatives / metabolism Humans Mutation Rats United States United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
|
0/Butylene Glycols; 0/Food Additives; 0/Food Preservatives |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of sodium salicylate on the cerebral blood circulation (an experimental and clinical study)
Next Document: Studies on sperm antigenicity. 2. In vivo and in vitro cellular reactivity in guinea pigs sensitized...