Document Detail


Nutritional manipulation of primate retinas, V: effects of lutein, zeaxanthin, and n-3 fatty acids on retinal sensitivity to blue-light-induced damage.
MedLine Citation:
PMID:  21245404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Blue-light photooxidative damage has been implicated in the etiology of age-related macular degeneration (AMD). The macular pigment xanthophylls lutein (L) and zeaxanthin (Z) and n-3 fatty acids may reduce this damage and lower the risk of AMD. This study investigated the effects of the lifelong absence of xanthophylls followed by L or Z supplementation, combined with the effects of n-3 fatty acid deficiency, on acute blue-light photochemical damage.
METHODS: Subjects included eight rhesus monkeys with no lifelong intake of xanthophylls and no detectable macular pigment. Of these, four had low n-3 fatty acid intake and four had adequate intakes. Control subjects had typical L, Z, and n-3 fatty acid intake. Retinas received 150-μm-diameter exposures of low-power 476-nm laser light at 0.5 mm (∼2°) eccentricity, which is adjacent to the macular pigment peak, and parafoveally at 1.5 mm (∼6°). Exposures of xanthophyll-free animals were repeated after supplementation with pure L or Z for 22 to 28 weeks. Ophthalmoscopically visible lesion areas were plotted as a function of exposure energy, with greater slopes of the regression lines indicating greater sensitivity to damage.
RESULTS: In control animals, the fovea was less sensitive to blue-light-induced damage than the parafovea. Foveal protection was absent in xanthophyll-free animals but was evident after supplementation. In the parafovea, animals low in n-3 fatty acids showed greater sensitivity to damage than animals with adequate levels.
CONCLUSIONS: After long-term xanthophyll deficiency, L or Z supplementation protected the fovea from blue light-induced damage, whereas adequate n-3 fatty acid levels reduced the damage in the parafovea.
Authors:
Felix M Barker; D Max Snodderly; Elizabeth J Johnson; Wolfgang Schalch; Wolfgang Koepcke; Joachim Gerss; Martha Neuringer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-06-06
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-08-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3934-42     Citation Subset:  IM    
Affiliation:
Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animal Nutritional Physiological Phenomena / physiology
Animals
Dietary Supplements
Disease Models, Animal
Fatty Acids, Omega-3 / administration & dosage*,  metabolism
Fovea Centralis / metabolism,  pathology,  radiation effects
Light / adverse effects*
Lutein / administration & dosage*,  deficiency
Macaca mulatta
Macular Degeneration* / diet therapy,  metabolism,  pathology
Oxidative Stress / physiology,  radiation effects
Radiation-Protective Agents / administration & dosage,  metabolism
Xanthophylls / administration & dosage*,  deficiency
Grant Support
ID/Acronym/Agency:
DK29930/DK/NIDDK NIH HHS; P30 EY03790/EY/NEI NIH HHS; RR00163/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Radiation-Protective Agents; 0/Xanthophylls; 127-40-2/Lutein; 144-68-3/zeaxanthin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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