Document Detail


Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia.
MedLine Citation:
PMID:  22893204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The strong link between inflammation and colorectal carcinogenesis provides the rationale for using anti-inflammatory agents for chemoprevention of colorectal cancer (CRC). Several naturally occurring substances with anti-inflammatory properties, used in a purified 'nutraceutical' form, including omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and polyphenols such as curcumin and resveratrol, have been demonstrated to have anti-CRC activity in preclinical models. As expected, these agents have an excellent safety and tolerability profile in Phase II clinical trials. Phase III randomized clinical trials of these naturally occurring substances are now beginning to be reported. The omega-3 polyunsaturated fatty acid EPA, in the free fatty acid (FFA) form, has been demonstrated to reduce adenomatous polyp number and size in patients with familial adenomatous polyposis (FAP), a finding which has prompted evaluation of this formulation of EPA for prevention of 'sporadic' colorectal neoplasia. Anti-inflammatory 'nutraceuticals' require further clinical evaluation in polyp prevention trials as they exhibit many of the characteristics of the ideal cancer chemoprevention agent, including safety, tolerability and patient acceptability.
Authors:
Mark A Hull
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  191     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-15     Completed Date:  2012-11-08     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  143-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / pharmacology*
Anticarcinogenic Agents / pharmacology*
Colorectal Neoplasms / prevention & control*
Curcumin / pharmacology
Dietary Supplements
Fatty Acids, Omega-3 / pharmacology
Humans
Stilbenes / pharmacology
Vitamin D / pharmacology
Grant Support
ID/Acronym/Agency:
G116/146//Medical Research Council
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anticarcinogenic Agents; 0/Fatty Acids, Omega-3; 0/Stilbenes; 1406-16-2/Vitamin D; IT942ZTH98/Curcumin; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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