| Nutrition support with glutamine dipeptide in patients undergoing liver transplantation. | |
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MedLine Citation:
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PMID: 20005375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The effect of total parenteral nutrition (TPN) support supplemented with alanyl-glutamine (Ala-Gln) dipeptide was investigated in a randomized, controlled clinical trial. METHODS: Sixty-five patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma admitted for orthotopic liver transplantation were randomly divided into 3 groups: diet group (n = 21), TPN group (n = 22), and Gln group (n = 22). Patients in the TPN and Gln groups received isocaloric and isonitrogenous TPN for 7 days. Venous heparin blood samples were obtained for assay on days 2 and 9 after surgery; we performed routine pathologic tests. RESULTS: Compared with the results on day 9 in the TPN group, there was a significant increase in the prognostic nutrition index and in prealbumin among the Gln group. Aspartate aminotransferase improved significantly by Gln treatment compared with traditional TPN support (P < .05). The pathologic results also showed Gln supplementation to reduce hepatic cell injury. A significant decrease in postoperative hospital stay was observed in the Gln group. CONCLUSIONS: Posttransplant TPN support greatly improved protein metabolism and nutritional state of patients. TPN with Ala-Gln helped to improve synthetic function and to reduce the injury to a transplanted liver. |
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Authors:
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Y Qiu; X Zhu; W Wang; Q Xu; Y Ding |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Transplantation proceedings Volume: 41 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-04-23 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 4232-7 Citation Subset: IM |
Affiliation:
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Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Zhongshang Road 321, Nanjing 210008, China. yudongqiu510@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Blood Proteins / analysis Dietary Supplements Dipeptides / administration & dosage*, therapeutic use Female Humans Liver Transplantation* / pathology Lymphocyte Count Male Middle Aged Nutritional Support / methods* Parenteral Nutrition, Total Patient Selection Prealbumin Serum Albumin / analysis Transferrin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Dipeptides; 0/Prealbumin; 0/Serum Albumin; 0/Transferrin; U5JDO2770Z/alanylglutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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