Document Detail

Nutrition support with glutamine dipeptide in patients undergoing liver transplantation.
MedLine Citation:
PMID:  20005375     Owner:  NLM     Status:  MEDLINE    
AIM: The effect of total parenteral nutrition (TPN) support supplemented with alanyl-glutamine (Ala-Gln) dipeptide was investigated in a randomized, controlled clinical trial.
METHODS: Sixty-five patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma admitted for orthotopic liver transplantation were randomly divided into 3 groups: diet group (n = 21), TPN group (n = 22), and Gln group (n = 22). Patients in the TPN and Gln groups received isocaloric and isonitrogenous TPN for 7 days. Venous heparin blood samples were obtained for assay on days 2 and 9 after surgery; we performed routine pathologic tests.
RESULTS: Compared with the results on day 9 in the TPN group, there was a significant increase in the prognostic nutrition index and in prealbumin among the Gln group. Aspartate aminotransferase improved significantly by Gln treatment compared with traditional TPN support (P < .05). The pathologic results also showed Gln supplementation to reduce hepatic cell injury. A significant decrease in postoperative hospital stay was observed in the Gln group.
CONCLUSIONS: Posttransplant TPN support greatly improved protein metabolism and nutritional state of patients. TPN with Ala-Gln helped to improve synthetic function and to reduce the injury to a transplanted liver.
Y Qiu; X Zhu; W Wang; Q Xu; Y Ding
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Transplantation proceedings     Volume:  41     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-23     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4232-7     Citation Subset:  IM    
Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Zhongshang Road 321, Nanjing 210008, China.
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MeSH Terms
Blood Proteins / analysis
Dietary Supplements
Dipeptides / administration & dosage*,  therapeutic use
Liver Transplantation* / pathology
Lymphocyte Count
Middle Aged
Nutritional Support / methods*
Parenteral Nutrition, Total
Patient Selection
Serum Albumin / analysis
Transferrin / metabolism
Reg. No./Substance:
0/Blood Proteins; 0/Dipeptides; 0/Prealbumin; 0/Serum Albumin; 0/Transferrin; U5JDO2770Z/alanylglutamine

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