Document Detail

Nutrition and skin ulcers.
MedLine Citation:
PMID:  23222706     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Skin ulcerations cause significant morbidity and mortality, while driving up healthcare utilization and costs. Interventions to prevent ulcers and improve wound healing times are needed to reduce the burden on patients and healthcare systems. It has been well established that weight loss, protein-calorie malnutrition, and dehydration are risk factors for pressure ulcers. Many nutritional interventions have been studied, with studies being of variable quality and producing mixed results. This review aims to clarify the current evidence and highlights the recent advances in the area of nutrition for the prevention and management of skin ulceration.
RECENT FINDINGS: Markers for assessing nutritional status will be reviewed first, followed by a discussion on the theoretical benefit of various nutritional interventions on wound healing. Recommendations for nutrient repletion are also included. Finally, the most recent or important literature will be highlighted and the risks and benefits of supplementation are debated. There is mixed evidence for most nutritional interventions, with most studies being of poor quality with variable study designs, lack of control groups, small sample sizes, and short study lengths.
SUMMARY: Long-term randomized trials of individual nutrients and clinically relevant endpoints are needed to definitively show the benefit of additional nutritional supplementation over dietary interventions. Until those studies become available, best evidence suggests the importance of screening for malnutrition, calculating resting energy expenditure and caloric needs, and monitoring dietary intake of essential nutrients.
Milta O Little
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  16     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-14     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Division of Geriatric Medicine, Department of Internal Medicine, Saint Louis University Medical Center, Saint Louis, Missouri 63104, USA.
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MeSH Terms
Antioxidants / administration & dosage
Biological Markers / blood
Dietary Proteins / administration & dosage
Dietary Supplements*
Energy Intake
Energy Metabolism
Micronutrients / administration & dosage
Nutrition Assessment
Nutritional Status*
Pressure Ulcer / etiology,  physiopathology*,  prevention & control
Protein-Energy Malnutrition / complications,  physiopathology*
Risk Factors
Wound Healing / drug effects
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Dietary Proteins; 0/Micronutrients
Erratum In:
Curr Opin Clin Nutr Metab Care. 2013 May;16(3):373

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