Document Detail

Nutrition and respiratory disease.
MedLine Citation:
PMID:  6426844     Owner:  NLM     Status:  MEDLINE    
Correlations between nutritional status and respiratory function, effects of nutritional substrates on respiration, and optimal nutritional support during respiratory failure are reviewed. Somatic protein depletion is common in patients with either acute respiratory failure or chronic obstructive pulmonary disease. The etiology of the malnutrition includes decreased nutrient intake, increased work of breathing, and increased metabolic rate caused by infections. Excessive administration of glucose or protein can have detrimental effects on respiratory status. Weaning patients from ventilators may be prolonged or even impossible secondary to increased carbon dioxide production in patients receiving high caloric loads of glucose. Excessive protein administration stimulates ventilatory drive and can be detrimental in patients who cannot increase their minute ventilation. Fat is the preferred substrate for energy in selected mechanically ventilated patients requiring total parenteral nutrition because it is oxidized at a lower respiratory quotient than glucose. Measurements of respiratory quotient, oxygen consumption, and carbon dioxide production can be useful in providing optimal nutritional support to the patient with respiratory compromise.
R O Brown; W D Heizer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical pharmacy     Volume:  3     ISSN:  0278-2677     ISO Abbreviation:  Clin Pharm     Publication Date:    1984 Mar-Apr
Date Detail:
Created Date:  1984-06-26     Completed Date:  1984-06-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207437     Medline TA:  Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  152-61     Citation Subset:  IM    
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MeSH Terms
Fat Emulsions, Intravenous / adverse effects,  therapeutic use
Lung / physiopathology
Muscles / physiopathology
Nutrition Disorders / etiology,  physiopathology
Nutritional Physiological Phenomena*
Parenteral Nutrition, Total
Respiratory Tract Diseases / complications,  physiopathology*
Reg. No./Substance:
0/Fat Emulsions, Intravenous

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