| Nutrition in early life and risk of childhood leukemia: a case-control study in Greece. | |
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MedLine Citation:
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PMID: 23179662 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: There is a paucity of findings concerning the role of diet in childhood leukemogenesis, whereas the results are equivocal and the studies heterogeneous with regard to food items examined. This case-control study investigates the association of childhood leukemia with food groups, macronutrient consumption, total energy intake and adherence to Mediterranean diet among children aged 5-14 years in Greece. METHODS: A total of 139 consecutive, incident leukemia cases out of which 121 were acute lymphoblastic leukemia were derived from the Nationwide Registry for Childhood Hematological Malignancies along with one : one age- and gender-matched hospital controls. Information on socio-demographic, maternal and child variables and dietary habits was obtained through in-person interviews with the guardians/children. Multiple logistic regression was performed with adjustment for birth weight and possible confounding variables. RESULTS: Higher consumption of added lipids was associated with an increased risk of childhood leukemia, whereas consumption of milk and dairy products with reduced risk. From the macronutrient analysis, a borderline trend linking high protein intake with reduced childhood leukemia risk was observed. CONCLUSION: Consumption of milk and dairy products in the first year of life may protect against childhood leukemia possibly through vitamin D actions, while added lipids may increase the risk through various mechanisms. These results offer a holistic evaluation of children's nutrition and suggest that dietary habits in the early years of life may contribute to the prevention of childhood leukemia. |
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Authors:
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Andreas-Antonios Diamantaras; Nick Dessypris; Theodoros N Sergentanis; Evangelos Ntouvelis; Fani Athanasiadou-Piperopoulou; Margarita Baka; Ioanna Fragandrea; Maria Moschovi; Sofia Polychronopoulou; Eftichia Stiakaki; Demosthenes Panagiotakos; Eleni Petridou |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-21 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: - ISSN: 1573-7225 ISO Abbreviation: Cancer Causes Control Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 M. Asias Str. Goudi, 115 27, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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