| Nutrition and immunity: the immunoregulatory effect of n-6 essential fatty acids is mediated through prostaglandin E. | |
| | |
MedLine Citation:
|
PMID: 4040494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Suppression of cell-mediated immune responses by essential fatty acids (EFA) was demonstrated in mice maintained on a standard laboratory diet for rodents. Daily oral administration of EFA at doses ranging from 125 to 750 mg/kg body weight significantly suppressed local host-versus-graft and graft-versus-host reactions as measured by popliteal lymph node assay. Studies employing immune sera directed against E-type prostaglandin demonstrated that n-6 EFA-induced suppression was mediated through prostaglandin E1. In titration experiments the effect of n-6 EFA on the reactions was dose dependent with enhancement of the responses at low concentrations and suppression at high concentrations. |
| | |
Authors:
|
J Mertin; A Stackpoole; S Shumway |
Related Documents
:
|
17961574 - Prevention of postpartum hemorrhage with misoprostol. 6704144 - Protective effect of 16,16-dimethyl prostaglandin e2 on the hepatotoxicity of bromobenz... 8248384 - Sodium diclofenac inhibits hyperthermia induced by paradoxical sleep deprivation: the p... 14636824 - A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate ... 22535574 - A phase 1 dose escalation study of bortezomib combined with rituximab, cyclophosphamide... 10919684 - Clinical efficacy and safety of fluticasone propionate 1 mg per day administered via a ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International archives of allergy and applied immunology Volume: 77 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1985 |
Date Detail:
|
Created Date: 1985-09-16 Completed Date: 1985-09-16 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 390-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alprostadil Animals Antibodies / immunology Fatty Acids, Essential / immunology*, pharmacology Graft vs Host Reaction / drug effects Host vs Graft Reaction / drug effects Immunity, Cellular* / drug effects Immunosuppression Mice Mice, Inbred Strains Nutritional Physiological Phenomena* Prostaglandins E / immunology* Spleen / transplantation Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies; 0/Fatty Acids, Essential; 0/Prostaglandins E; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Studies on the effects of estrogen on the antibody response in asymptomatic HB virus carrier.
Next Document: Changes in intratesticular testosterone, cytoplasmic androgen receptors and ABP content of the ram t...