Document Detail

Nutrition changes in conservatively treated patients with encapsulating peritoneal sclerosis.
MedLine Citation:
PMID:  23818004     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Encapsulating peritoneal sclerosis (EPS), a rare but serious complication of long-term PD, is characterized by nausea, abdominal pain, weight loss, anorexia, and constipation. It can cause a significant deterioration in a patient's nutrition status. In the present study we examined changes in nutrition status and outcomes for patients with EPS treated conservatively without the use of surgical intervention.
METHODS: Patients diagnosed with EPS at our institution between December 2006 and December 2010 were identified, and data on demographics, nutrition, and symptoms were collected every 2 months for 12 months and then at 18 and 24 months.
RESULTS: Of the 15 patients identified, 12 were malnourished or at risk of malnutrition according to their subjective global assessment score, with 11 of the 15 presenting with more than 10% weight loss in the 6 months before diagnosis. Furthermore, symptom burden was high, with 11 of 15 patients reporting 2 or more gastrointestinal symptoms. Of the 15 patients, 12 required parenteral nutrition for a median of 4.5 months, and 5 died within the first 12 months after diagnosis. In the 10 survivors, albumin and C-reactive protein significantly improved over the 24 months after diagnosis. Improving trends in weight and symptoms were also observed in those patients.
CONCLUSIONS: In some patients with EPS, a conservative approach without surgical intervention, and with regular dietetic input and aggressive nutrition support, can lead to improved nutrition status and symptoms.
Nevine El-Sherbini; Neill Duncan; Mary Hickson; Lina Johansson; Edwina A Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-07-01
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  33     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2013 Sep-Oct
Date Detail:
Created Date:  2013-10-17     Completed Date:  2014-07-10     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  538-43     Citation Subset:  IM    
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MeSH Terms
Body Weight
Follow-Up Studies
Kidney Failure, Chronic / blood,  therapy
Malnutrition / enzymology,  etiology*,  therapy
Middle Aged
Nutrition Assessment*
Nutritional Status*
Parenteral Nutrition / methods*
Peritoneal Dialysis / adverse effects*
Peritoneal Fibrosis / complications,  enzymology,  therapy*
Retrospective Studies
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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