Document Detail


Nutrition and biomembranes: additional information concerning the incidence of dietary polyunsaturated fatty acids on membrane organization and biological activity.
MedLine Citation:
PMID:  2541797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the important questions in biomembranes now is: Do the essential fatty acids (polyunsaturated fatty acids of the n-6 and n-3 series) play an original structural role in the arrangement of the lipid matrix capable, in particular, of triggering modifications of intrinsic protein activities? Preliminary results from our laboratories are presented in rat and piglet fed standard or essential fatty acid-deficient diets. The relative amounts of 18:2 (n-6) and 20:4 (n-6) in total fatty acids of hepatic microsome or enterocyte brush border membrane phospholipids are closely dependent on the type of diet (a globally decreasing effect with deficiency), whereas no differences were observed with relative amounts of cholesterol, phospholipids, and proteins. This effect of deficiency on membrane fatty acids has to be compared to the decreasing specific activities of microsome NADPH-cytochrome c reductase or aniline hydroxylase (studied in rat), to the increasing order of the structure of both membrane microsome and brush border lipid matrix (studied in both rat and piglet), and to the increasing mobility (or accessibility) of the membrane-protein surface-bonded spin-label (studied in the piglet brush border membrane), suggesting a probably defective protein-lipid fit in the case of deficiency. These results could favor conformational change in the whole membrane structure (i.e. proteins and lipids). The specificity of these effects remains to be assessed.
Authors:
C L Léger; R Christon; J Viret; D Daveloose; S Mitjavila; V Even
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimie     Volume:  71     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-29     Completed Date:  1989-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Affiliation:
Station de Recherches de Nutrition, I.N.R.A., Centre de Recherches de Jouy-en-Josas, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Thin Layer
Electron Spin Resonance Spectroscopy
Fatty Acids, Essential / deficiency
Intracellular Membranes / analysis
Membrane Proteins / analysis
Microsomes, Liver / analysis*
Microvilli / analysis*
Phospholipids / analysis
Rats
Rats, Inbred Strains
Swine
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Membrane Proteins; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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