| Nutrition and biomembranes: additional information concerning the incidence of dietary polyunsaturated fatty acids on membrane organization and biological activity. | |
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MedLine Citation:
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PMID: 2541797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the important questions in biomembranes now is: Do the essential fatty acids (polyunsaturated fatty acids of the n-6 and n-3 series) play an original structural role in the arrangement of the lipid matrix capable, in particular, of triggering modifications of intrinsic protein activities? Preliminary results from our laboratories are presented in rat and piglet fed standard or essential fatty acid-deficient diets. The relative amounts of 18:2 (n-6) and 20:4 (n-6) in total fatty acids of hepatic microsome or enterocyte brush border membrane phospholipids are closely dependent on the type of diet (a globally decreasing effect with deficiency), whereas no differences were observed with relative amounts of cholesterol, phospholipids, and proteins. This effect of deficiency on membrane fatty acids has to be compared to the decreasing specific activities of microsome NADPH-cytochrome c reductase or aniline hydroxylase (studied in rat), to the increasing order of the structure of both membrane microsome and brush border lipid matrix (studied in both rat and piglet), and to the increasing mobility (or accessibility) of the membrane-protein surface-bonded spin-label (studied in the piglet brush border membrane), suggesting a probably defective protein-lipid fit in the case of deficiency. These results could favor conformational change in the whole membrane structure (i.e. proteins and lipids). The specificity of these effects remains to be assessed. |
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Authors:
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C L Léger; R Christon; J Viret; D Daveloose; S Mitjavila; V Even |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimie Volume: 71 ISSN: 0300-9084 ISO Abbreviation: Biochimie Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-06-29 Completed Date: 1989-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1264604 Medline TA: Biochimie Country: FRANCE |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Station de Recherches de Nutrition, I.N.R.A., Centre de Recherches de Jouy-en-Josas, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, Thin Layer Electron Spin Resonance Spectroscopy Fatty Acids, Essential / deficiency Intracellular Membranes / analysis Membrane Proteins / analysis Microsomes, Liver / analysis* Microvilli / analysis* Phospholipids / analysis Rats Rats, Inbred Strains Swine |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Membrane Proteins; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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