Document Detail


[Cinacalcet hydrochloride and phosphate metabolism].
MedLine Citation:
PMID:  23023638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of cinacalcet hydrochloride (cinacalcet) on blood phosphorus (P) levels is widely-accepted. However, this effect is only observed in patients on dialysis. Reduction in parathyroid hormone (PTH) induced by cinacalcet increases blood P levels with decreased urinary P excretion in pre-dialysis patients with chronic kidney disease (CKD). Similar results observed in normal and CKD rats provide a pharmacological validation of the trade-off hypothesis. The lowering effect of cinacalcet on blood P levels in dialysis patients is attributed to decreased P mobilization from the bone caused by the decreased PTH secretion. It is unlikely that this P-lowering effect of cinacalcet would bring any benefits on the enhanced parathyroid gland function and bone metabolism. On the other hand, the P-lowering effect of this drug is considered to contribute to its inhibitory effects on the development and progression of vascular calcification in dialysis patients. Further studies should examine this beneficial cinacalcet effect would lead to the reduction of the mortality risk.
Authors:
Nobuo Nagano; Tetsuo Ando; Kyoko Ito; Ando Yoshitaka
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Clinical calcium     Volume:  22     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-03-20     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1567-76     Citation Subset:  IM    
Affiliation:
Hidaka Research Center, Takasaki, Gunma/Medical Center East, Tokyo Women's University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Humans
Naphthalenes / adverse effects,  therapeutic use*
Parathyroid Glands / drug effects
Parathyroid Hormone / metabolism*
Phosphorus / metabolism*
Renal Dialysis
Renal Insufficiency, Chronic / drug therapy
Chemical
Reg. No./Substance:
0/Naphthalenes; 0/Parathyroid Hormone; 7440-70-2/Calcium; 7723-14-0/Phosphorus; UAZ6V7728S/cinacalcet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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