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[Nutrition and Phosphorus - New progress and problem - . Phosphate sensing and osteocyte].
MedLine Citation:
PMID:  23023636     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Osteocyte expresses molecules responsible for hereditary hypophosphatemic rickets such as FGF23, DMP1 and PHEX. FGF23 exerts its effects in kidney by decreasing both renal phosphate (Pi) reabsorption and vitamin D activation. It is suggested that DMP1 and PHEX negatively regulate the expression of FGF23, although the underlying mechanisms remain to be elucidated. Circulating level of FGF23 appears to be regulated by systemic factors as well, including vitamin D and PTH. Although it is unknown how mammals sense the Pi availability, it has been recently reported that extracellular Pi itself triggers signal transduction in some cell types such as osteoblasts and chondrocytes, suggesting that osteocytes also respond to the alteration in extracellular Pi level.
Authors:
Toshimi Michigami
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  22     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1551-6     Citation Subset:  IM    
Affiliation:
Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
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