Document Detail

[Nutrition and Phosphorus - New progress and problem - . Klotho and phosphate metabolism].
MedLine Citation:
PMID:  23023633     Owner:  NLM     Status:  In-Data-Review    
α-Klotho was first identified as an aging gene and was later shown to be a regulator of mineral metabolism. Then, α-Klotho was reported to function as an obligate coreceptor for fibroblast growth factor 23 (FGF23). Phosphrus regulation of FGF23/Klotho axis is slow. On the other hand, α-Klotho is a key player that integrates "a multi-step regulatory system of calcium homeostasis" that rapidly adjusts the extracellular calcium concentration. In addition to its membrane-bound function as a co-receptor for fibroblast growth factor 23, soluble Klotho exerts effects as a circulating substance in plasma and urine. The Klotho protein not only serves as a coreceptor for FGF23, but also functions as a humoral factor.
Keitaro Yokoyama
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  22     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1531-6     Citation Subset:  IM    
Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
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