Document Detail

[Nutrition and Phosphorus - New progress and problem - . Significance of FGF23 measurement].
MedLine Citation:
PMID:  23023632     Owner:  NLM     Status:  In-Data-Review    
Excess and deficient actions of FGF23 cause hypophosphatemic rickets/osteomalacia and hyperphosphatemic tumoral calcinosis, respectively. There are two kinds of assays for FGF23. Full-length assay detects only full-length FGF23 with biological activity. In contrast, C-terminal assay measures both full-length FGF23 and processed C-terminal fragment of FGF23. FGF23 measurement is useful for the diagnosis and follow-up of patients with FGF23-related hypophosphatemic diseases. In addition, full-length assay can be used for the differential diagnosis of hypophosphatemic diseases. Furthermore, many epidemiological studies indicated the association between FGF23 levels and several adverse events including higher mortality, cardiovascular diseases and progression of CKD especially in patients with CKD. Therefore, it is possible that FGF23 can be a new marker in the risk assessment of patients with CKD.
Seiji Fukumoto
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Clinical calcium     Volume:  22     ISSN:  0917-5857     ISO Abbreviation:  Clin Calcium     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433326     Medline TA:  Clin Calcium     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  1525-9     Citation Subset:  IM    
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
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