| [Nutrition and Phosphorus - New progress and problem - . Hyperphosphatemia and cardiovascular diseases : Impact of vascular calcification and endothelial dysfunction]. | |
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MedLine Citation:
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PMID: 23023630 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Hyperphosphatemia has clinically been associated with total mortality and cardiovascular mortality in patients with chronic renal failure (CRF). Recently, higher serum phosphate levels within the normal range have been shown to be associated with substantially increased risk of cardiovascular events even in patients without CRF. Therefore, it is clear that the phosphate axis may in fact play a role in atherogenesis. Accumulating mechanistic studies regarding local effects of phosphate on the vessel wall have recently provided insight into various pathways that culminate in vascular smooth muscle cell (SMC) calcification. SMC phenotypic change into osteochondrogenic differentiation and SMC apoptosis are essential roles in hyperphosphatemia-induced vascular calcification. In addition, Hyperphosphatemia induces endothelial dysfunction via various mechanisms, including a decline in nitric oxide release due to oxidative stress. The sodium-dependent phosphate cotransporter PiT-1 is required for these effects. This review shows the current knowledge about phosphate-induced changes in the vascular wall, leading to atherosis and sclerosis. |
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Authors:
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Katsuya Iijima |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Clinical calcium Volume: 22 ISSN: 0917-5857 ISO Abbreviation: Clin Calcium Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433326 Medline TA: Clin Calcium Country: Japan |
Other Details:
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Languages: jpn Pagination: 1505-13 Citation Subset: IM |
Affiliation:
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Institute of Gerontology, The University of Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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