Document Detail


Nutrition and L and K-enteroendocrine cells.
MedLine Citation:
PMID:  21124210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are summarized in this review.
RECENT FINDINGS: This study provides an overview of recent advances in our understanding of the physiology of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as of oxyntomodulin. A better understanding of the secretion and action of these hormones at their receptors was made possible by new techniques that allow investigation of individual enteroendocrine cells.
SUMMARY: The better understanding of the function of the gastrointestinal incretin hormones and their implications for improving glucose homeostasis and perhaps influencing food intake and appetite as well, new research in this area will help combat metabolic diseases such as type 2 diabetes and obesity.
Authors:
Ruth Gutierrez-Aguilar; Stephen C Woods
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  18     ISSN:  1752-2978     ISO Abbreviation:  Curr Opin Endocrinol Diabetes Obes     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-23     Completed Date:  2011-03-31     Revised Date:  2014-01-16    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Design
Enteroendocrine Cells / classification,  cytology,  metabolism,  physiology*
Gastric Inhibitory Polypeptide / genetics,  metabolism,  physiology
Glucagon-Like Peptide 1 / genetics,  metabolism,  physiology
Humans
Incretins / genetics,  metabolism,  physiology
Models, Biological
Nutritional Physiological Phenomena* / genetics
Grant Support
ID/Acronym/Agency:
DK 017844/DK/NIDDK NIH HHS; R01 DK017844/DK/NIDDK NIH HHS; R01 DK017844-35/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Incretins; 59392-49-3/Gastric Inhibitory Polypeptide; 89750-14-1/Glucagon-Like Peptide 1
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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