| Nutrigenetic determinants of neural tube defects in India. | |
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MedLine Citation:
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PMID: 19556657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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JUSTIFICATION: Neural tube defects (NTDs) are one of the commonest birth defects with a high incidence in India. However, few studies have systematically looked into the etio-pathogeneis of NTDs, which mainly includes nutritional deficiencies and genetic predisposition. Efforts are afoot for universal food fortification with folic acid in the hope of preventing NTDs, without factual evidence of folate deficiency in the target population. EVIDENCE ACQUISITION: We conducted a review of Indian literature on NTDs focusing on the role of folate and vitamin B12 nutrition and common genetic polymorphisms in 1-carbon metabolism. We performed a literature search of Medline and Indian Medlars (www. indmed.nic.in) for articles using following search terms: Neural tube defect and India, published up to November 2008, on human subjects. We did not include individual case reports and case series describing surgical and medical management, genetic syndromes where NTD was only one of the features or unusual associations of NTDs with other clinical findings. RESULTS: Absence of a nationally representative large study, lack of interventional studies and methodological differences were conspicuous during this review. Larger studies are, therefore, urgently needed to delineate genenutrient interactions in association with NTDs in India. We urge that caution should be exercised before widespread folic acid fortification of food, without addressing the issue of concurrent B12 deficiency. |
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Authors:
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Koumudi Godbole; Urmila Deshmukh; Chittaranjan Yajnik |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian pediatrics Volume: 46 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-26 Completed Date: 2009-09-02 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 467-75 Citation Subset: IM |
Affiliation:
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Diabetes Unit, KEM Hospital, Pune, India. koumudig@rediffmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Folic Acid Deficiency
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genetics Genetic Predisposition to Disease Humans Hyperhomocysteinemia / genetics India / epidemiology Neural Tube Defects / epidemiology, genetics* Nutrigenomics* Polymorphism, Genetic Vitamin B 12 Deficiency / genetics |
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