Document Detail

Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer.
MedLine Citation:
PMID:  23620017     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design.
METHODS: Our study included 384 rapidly ascertained cases and 983 controls frequency-matched on age at time of recruitment (in 5-year increments), race, sex, and region of residence. All subjects provided demographic information and completed a 144-item food frequency questionnaire in which they reported no change to their diet within 5 years prior to entering the study. Logistic regression was used to calculate odds ratios and 95 % confidence intervals, adjusted for age, sex, smoking, body mass index, energy intake, and alcohol consumption.
RESULTS: Results show a significant (trend p value < 0.05) inverse association between pancreatic cancer and nutrient/supplement groupings in a dose-dependent manner including magnesium, potassium, selenium, alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein and zeaxanthin, niacin, total alpha-tocopherol, total vitamin A activity, vitamin B6, and vitamin C. Adjusting for diabetes or total sugar intake did not result in significant changes.
CONCLUSION: We conclude that most nutrients obtained through consumption of fruits and vegetables may reduce the risk of developing pancreatic cancer.
Rick J Jansen; Dennis P Robinson; Rachael Z Stolzenberg-Solomon; William R Bamlet; Mariza de Andrade; Ann L Oberg; Kari G Rabe; Kristin E Anderson; Janet E Olson; Rashmi Sinha; Gloria M Petersen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  44     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-11-06     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-61     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / epidemiology*
Case-Control Studies
Dietary Supplements
Odds Ratio
Pancreatic Neoplasms / epidemiology*
Risk Factors
Grant Support
P20 CA102701/CA/NCI NIH HHS; P50CA102701/CA/NCI NIH HHS; R25 CA092049/CA/NCI NIH HHS; R25TCA92049//PHS HHS

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