Document Detail


Nutrient utilisation in muscle and in the whole body of patients receiving total parenteral nutrition.
MedLine Citation:
PMID:  16840019     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Forearm metabolite exchange was assessed by the arterio-venous catheterization technique in 5 parenterally fed patients (weight 55.22 kg +/- 4.18 kg; height 1.71 m +/- 0.04 m), who received an 'all-in-one' nutrition regimen whilst in remission from Crohn's disease. All patients received 12.8 g N, 4725 kJ from carbohydrate and 4200 kJ from fat (10416 kJ total energy). The exchanges were related to nutrient oxidation and nutrient balances in the whole body as assessed by indirect calorimetry and nitrogen excretion. At rest, the subjects were found to be in positive balances for carbohydrate (+0.78 +/- 0.13 kJ/min), fat (+1.85 +/- 0.26 kJ/min) and protein (+0.240 +/- 0.04 kJ/min). Resting forearm muscle was also in positive amino acid balance and positive carbohydrate balance. Despite the large estimated uptake of glucose by forearm muscle (+1860 +/- 84 nmol/100 ml tissue/min) there was no net release of pyruvate and lactate. Glutamate and the branched chain amino acids (BCAA) were the dominant amino acids taken up by muscle (26% and 30% of total uptake respectively) and glutamine was the dominant amino acid carrying nitrogen out of muscle (78% of total amino acid nitrogen release). The energy taken up by muscle as non-esterified fatty acids, triacylglycerol and ketone bodies was small relative to that associated with glucose uptake. The results suggest that during the hypercaloric parenteral nutrition regimen, a) increased peripheral glucose uptake is not necessarily associated with increased release of glycolytic products, b) in the absence of glutamine intake for at least 10 days, muscle retains enough capacity to synthesise and release sufficient quantities of glutamine so that it remains the dominant amino acid carrying nitrogen out of muscle, c) despite the use of the intravenous route for administration of nutrients, and unusual amino acid composition of the regimen, the overall pattern of forearm metabolism bears many similarities to that which occurs after a mixed meal in normal subjects.
Authors:
K Khan; B A Baker; M Elia
Related Documents :
8987649 - Fermentation of molasses using a thermotolerant yeast, kluyveromyces marxianus imb3: si...
9467229 - Amino acid utilization and isotope discrimination of amino nitrogen in nitrogen metabol...
16663659 - Utilization of the amide groups of asparagine and 2-hydroxysuccinamic acid by young pea...
15601699 - Regulation of the pseudomonas sp. strain adp cyanuric acid degradation operon.
22282329 - Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fib...
3088969 - Protein nutrition and amino acid metabolism after 4 weeks of total parenteral nutrition...
16511089 - Initiating a crystallographic analysis of recombinant (s)-2-hydroxypropylphosphonic aci...
22635989 - Influence of artisan bakery- or laboratory-propagated sourdoughs on the diversity of la...
25176139 - Picosecond pulse radiolysis of highly concentrated phosphoric acid solutions: mechanism...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  11     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  1992 Dec 
Date Detail:
Created Date:  2006-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  -    
Affiliation:
Dunn Clinical Nutrition Centre, MRC & Cambridge University, 100 Tennis Court Road, Cambridge CB2 1QL, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Short term benefits of post-operative oral dietary supplements in surgical patients.
Next Document:  Acute IGF-1 deficiency in multiple trauma victims.