| Nutrient transport systems in brain: 40 years of progress. | |
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MedLine Citation:
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PMID: 19686385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the last 40 years, especially with the application of new neurochemical and molecular biologic techniques, there has been an explosive progress in understanding how nutrients are transported across the blood-brain barrier and choroid plexus into brain and CSF, and how nutrient homeostasis in brain is achieved. In most cases, there are separate transporters, or in a few cases, systems that transport related substances (e.g., biotin, lipoic, and pantothenic acids). This review focuses on three crucial nutrients (glucose, ascorbic acid, and folates) for which there is substantial new information including 'knock down' and 'knockout' models in mice and/or humans. The overall objective is to show that this new knowledge leads not just to a more thorough understanding (e.g., of 'why' questions like: why do neurons require up to 10 mM ascorbic acid intracellulary?); but in some cases leads to clinically important predictions that allow treatment of heretofore devastating neurologic disorders. |
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Authors:
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Reynold Spector |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-08-04 |
Journal Detail:
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Title: Journal of neurochemistry Volume: 111 ISSN: 1471-4159 ISO Abbreviation: J. Neurochem. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: England |
Other Details:
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Languages: eng Pagination: 315-20 Citation Subset: IM |
Affiliation:
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Department of Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA. mspec007@verizon.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / metabolism* Brain / metabolism* Glucose / metabolism* Homeostasis / physiology Humans Nutritional Physiological Phenomena / physiology* Vitamins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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