Document Detail

Nutrient-specific effects in the coordination of cell growth with cell division in continuous cultures of Saccharomyces cerevisiae.
MedLine Citation:
PMID:  15349714     Owner:  NLM     Status:  MEDLINE    
Cell cycle progression of Saccharomyces cerevisiae cells was monitored in continuous cultures limited for glucose or nitrogen. The G1 cell cycle phase, before initiation of DNA replication, did not exclusively expand when growth rate decreased. Especially during nitrogen limitation, non-G1 phases expanded almost as much as G1. In addition, cell size remained constant as a function of growth rate. These results contrast with current views that growth requirements are met before initiation of DNA replication, and suggest that distinct nutrient limitations differentially impinge on cell cycle progression.
Jinbai Guo; Brad A Bryan; Michael Polymenis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-09-02
Journal Detail:
Title:  Archives of microbiology     Volume:  182     ISSN:  0302-8933     ISO Abbreviation:  Arch. Microbiol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-13     Completed Date:  2004-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410427     Medline TA:  Arch Microbiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  326-30     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Springer-Verlag 2004
Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843, USA.
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MeSH Terms
Cell Cycle
Cell Division
Culture Media
DNA Replication
DNA, Fungal / biosynthesis
Saccharomyces cerevisiae / cytology*,  growth & development*,  metabolism
Grant Support
Reg. No./Substance:
0/Culture Media; 0/DNA, Fungal

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