Document Detail


Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring.
MedLine Citation:
PMID:  22921094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We hypothesized that gestationally programmed nonalcoholic fatty liver disease in low-birthweight offspring is mediated through nutrient sensors nicotinamide adenine dinucleotide+-dependent histone deacetylase (SIRT1) and AMP-activated protein kinase (AMPK).
STUDY DESIGN: Pregnant dams received ad libitum food or were 50% food restricted from pregnancy days 10-21 to produce control and low-birthweight newborn offspring, respectively. All pups were nursed by control dams and weaned to ad libitum feed. We determined hepatic SIRT1 and AMPK activities and protein expression of lipid targets in low-birthweight and control fetuses, newborns, and adult offspring (3 months).
RESULTS: Low-birthweight fetuses demonstrated increased prenatal hepatic SIRT1 activity, although with increased lipogenesis. After birth, low-birthweight newborn offspring undergo postnatal suppression of hepatic SIRT1 and AMPK activities in conjunction with increased lipogenesis, decreased lipolysis, and increased fat stores.
CONCLUSION: These findings suggest that undernutrition stress in utero may program hepatic nutrient sensors to perceive normal postnatal nutrition as a state of nutrient excess with the induction of hepatic lipid storage.
Authors:
Diana Wolfe; Ming Gong; Guang Han; Thomas R Magee; Michael G Ross; Mina Desai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-31
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-13     Revised Date:  2014-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adenylate Kinase / metabolism
Animals
Animals, Newborn
Body Weight / physiology
Fatty Liver / metabolism*
Female
Fetal Growth Retardation / metabolism*
Food Deprivation / physiology*
Liver / metabolism*
Pregnancy
Prenatal Exposure Delayed Effects / metabolism*
Rats
Rats, Sprague-Dawley
Sirtuin 1 / metabolism
Grant Support
ID/Acronym/Agency:
R01 DK081756/DK/NIDDK NIH HHS; R01 HD054751/HD/NICHD NIH HHS; R01DK081756/DK/NIDDK NIH HHS; R01HD054751/HD/NICHD NIH HHS; UL1 TR000124/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.4.3/Adenylate Kinase; EC 3.5.1.-/Sirt1 protein, rat; EC 3.5.1.-/Sirtuin 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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