Document Detail


Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus.
MedLine Citation:
PMID:  17211139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inadequate nutrition compromises fetal development and poses long-term health risks for the offspring, even without decreased birth weight. The present study sought to 1) establish the ontogeny of fetal renal glomerulus number (GN) in sheep and 2) evaluate the effects of 50% global nutrient restriction (NR) during early to midgestation on GN and the renin-angiotensin system in the fetal kidney. GN increased from 78 dG (68,560 +/- 3802) to 135 dG (586,118 +/- 25,792). NR increased combined kidney weight (29 +/- 0.6 g versus 23 +/- 1.1 g), whereas decreased GN relative to right kidney weight approached significance in males (26,000 +/- 5300 versus 39,000 +/- 2800 GN/g) compared with control (C) males and females. NR decreased immunoreactive angiotensin II (Ang II) type 1 receptor (AT1) in the NR kidneys at 78 dG and increased renin at 135 dG. Immunoreactive renin decreased from 78 to 135 dG. Female fetuses had more immunoreactive Ang II type 2 receptor (AT2) than male fetuses at 78 dG and males had more AT1 at 135 dG. The present study demonstrates gender-specific differences in fetal growth and development and in fetal kidney development in pregnancies affected by NR.
Authors:
Jeffrey S Gilbert; Stephen P Ford; A Lee Lang; Lindsay R Pahl; Mark C Drumhiller; Sara A Babcock; Peter W Nathanielsz; Mark J Nijland
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-02-07     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Center for the Study of Fetal Programming, University of Wyoming, Laramie, Wyoming 82071, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Eating / physiology*
Female
Fetus
Food*
Kidney Glomerulus / embryology*
Male
Pregnancy
Sex Factors
Sheep
Grant Support
ID/Acronym/Agency:
1P20RR16474-01/RR/NCRR NIH HHS; HD21350/HD/NICHD NIH HHS; HL65399/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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