Document Detail

Nutrient interaction for optimal protein anabolism in resistance exercise.
MedLine Citation:
PMID:  22366920     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrient interventions for cachectic populations. RECENT FINDINGS: Resistance exercise is a potent stimulus for MPS, but cachexia patients may not be best placed to lift the heavy loads that, it was previously assumed, were a prerequisite for muscle hypertrophy. However, recent evidence from our lab shows that lower loads can effectively stimulate MPS and lead to hypertrophy. Protein ingestion potentiates resistance exercise-induced rates of MPS. The source and dose of the ingested protein are important to consider when attempting to maximize postresistance exercise MPS. Specifically, rapidly digested, leucine-rich protein sources may stimulate greater postexercise rates of MPS than other protein sources, as leucine acts as a key anabolic signal for mRNA translation. Furthermore, individuals undergoing relatively slow muscle atrophy (i.e., in sarcopenic elderly) respond positively to larger doses (40 g) of amino acids following exercise, whereas the response appears to plateau after moderate doses (20 g) in healthy, young adults. SUMMARY: Emerging evidence shows that manipulating traditional exercise loading and nutrient strategies may ameliorate cachexia.
Leigh Breen; Stuart M Phillips
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  -     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
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