| Nutrient intakes in women and congenital diaphragmatic hernia in their offspring. | |
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MedLine Citation:
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PMID: 18181217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Congenital diaphragmatic hernia (CDH) is a severe birth defect where there is an opening in the diaphragm through which a portion of the abdominal contents protrudes into the thoracic cavity. The etiologies of CDH remain unknown, although experimental animal data suggest dietary factors might play a role. This study examined whether maternal nutrient intakes were associated with delivering infants with CDH. METHODS: We analyzed infants with isolated CDH who were born from 1997 to 2003 and recruited into the National Birth Defects Prevention Study (NBDPS), a multisite, population-based case-control study. Exposure data were obtained from telephone interviews, which were completed within 24 months after delivery, and were available for 377 case mothers and 5,008 control mothers. A food frequency questionnaire was used to derive nutrient intakes during the year before pregnancy. RESULTS: A crude OR of 0.6 (95% CI: 0.3-1.0) was observed for higher intake of choline. Elevated ORs (1.4 to 1.7) were found for lower intakes of choline, cysteine, methionine, and protein. Among women who took vitamin supplements, higher intakes of B vitamins (i.e., folate, vitamin B1, B2, B6, and B12), minerals (i.e., calcium, iron, magnesium, and zinc), and vitamin E were inversely associated with CDH (ORs from 0.7-0.3). Moreover, among women who did not take vitamin supplements, lower intakes of calcium, retinol, selenium, vitamin B12, and vitamin E had positive associations with CDH (ORs from 1.4 to 2.1). CONCLUSIONS: Our observations contribute to a limited body of evidence suggesting a woman's periconceptional diet might be associated with CDH in her offspring. |
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Authors:
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Wei Yang; Gary M Shaw; Suzan L Carmichael; Sonja A Rasmussen; D Kim Waller; Barbara R Pober; Marlene Anderka; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 82 ISSN: 1542-0760 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-18 Completed Date: 2008-08-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 131-8 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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March of Dimes, California Research Division, Oakland, California 94609, USA. WYang@marchofdimes.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Dietary Supplements Female Hernia, Diaphragmatic / congenital*, etiology Humans Infant, Newborn Maternal Nutritional Physiological Phenomena* Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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DK56350/DK/NIDDK NIH HHS; R01 HD55150/HD/NICHD NIH HHS; U50/CCU913241//PHS HHS |
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