| Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure. | |
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MedLine Citation:
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PMID: 20708308 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Dietary quality probably may impact heart failure outcomes. The aim of the study was to determine the potential effects of nutrient intake on homocysteine, MCP-1 and GGT levels in patients with heart failure. METHODS: The study group comprised 55 patients with diagnosed HF with coronary artery disease origin, below 65y, with NYHA class I/II. The patients had received standard treatment. The control comprised 55 patients with mild hyperlipidemia, not treated. Diet was evaluated on the basis of a dietary questionnaire and a 24-h dietary recall. The serum lipid profile, folic acid, homocysteine, GGT and MCP-1 were determined. RESULTS: In the HF group significantly higher concentration of homocysteine (32%), MCP-1 (58%) and GGT (100%) are found as compared to the control group (p < 0.00001). Patients with HF had greater cholesterol consumption, with less folates, vitamin C and dietary fiber as compared to the control group (p < 0.05). CONCLUSION: High consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients. |
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Authors:
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Magdalena Makarewicz-Wujec; Malgorzata Kozlowska-Wojciechowska |
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Publication Detail:
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Type: Journal Article Date: 2010-08-13 |
Journal Detail:
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Title: Clinical nutrition (Edinburgh, Scotland) Volume: 30 ISSN: 1532-1983 ISO Abbreviation: Clin Nutr Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Affiliation:
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Department of Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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