| Nutrient intake and immune function of elderly subjects. | |
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MedLine Citation:
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PMID: 19027403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Food intake, aging, and immune function share complex influences. Therefore, the purpose of this study was to examine relationships between nutrient intakes from food and dietary supplements and a biomarker of immune function. DESIGN: Data were collected from participants in a cross-sectional study as well as baseline data from a longitudinal study (n=89). Subjects completed 24-hour food recalls, including supplement intake. Polyclonal mitogen phytohemmagluttin (PHA) was the immune function stimulator used. Height and weight were used to calculate body mass index. STATISTICAL ANALYSES PERFORMED: Descriptive, bivariate correlation, Spearman's rho for nonparametric data, t tests, and stepwise regression with nutrient intakes as independent variables and T-cell proliferation as dependent variables. RESULTS: Significant positive correlations (P< or =0.05) were found between PHA-induced proliferation and intake of docosahexaenoic acid (DHA), eicosahexaenoic acid (EPA), sodium, and selenium, although intakes of DHA plus EPA were inadequate when compared to recommended intakes. A significant negative correlation with total vitamin A, with many vitamin A levels being above the upper limit of safety. Regression analyses found these nutrients to be variables significant in explaining the variance in PHA (P=0.005). CONCLUSIONS: Selenium, sodium, DHA, EPA, and vitamin A intake from diet and supplements were associated with PHA-induced proliferative responses. Clients may be counseled to have adequate selenium, EPA, DHA intake, and vitamin A, but avoid excess vitamin A. |
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Authors:
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Laura Wardwell; Karen Chapman-Novakofski; Susan Herrel; Jeffrey Woods |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 108 ISSN: 0002-8223 ISO Abbreviation: J Am Diet Assoc Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2009-01-29 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 2005-12 Citation Subset: AIM; IM |
Affiliation:
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Southern Illinois University School of Law, Carbondale, IL, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aging / physiology* Biological Markers Body Mass Index Cross-Sectional Studies Diet / standards*, statistics & numerical data Diet Surveys Dietary Fats, Unsaturated / administration & dosage* Dietary Supplements / statistics & numerical data, utilization Eating Energy Intake / physiology Female Geriatric Assessment Humans Immunity / drug effects, physiology* Longitudinal Studies Male Mental Recall Minerals / administration & dosage Nutritional Physiological Phenomena / physiology* Nutritional Requirements Phytohemagglutinins / immunology, toxicity Statistics, Nonparametric Vitamins / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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AG-18861/AG/NIA NIH HHS; R01 AG018861-03/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats, Unsaturated; 0/Minerals; 0/Phytohemagglutinins; 0/Vitamins |
| Comments/Corrections | |
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