Document Detail

Nutrient intake and immune function of elderly subjects.
MedLine Citation:
PMID:  19027403     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Food intake, aging, and immune function share complex influences. Therefore, the purpose of this study was to examine relationships between nutrient intakes from food and dietary supplements and a biomarker of immune function.
DESIGN: Data were collected from participants in a cross-sectional study as well as baseline data from a longitudinal study (n=89). Subjects completed 24-hour food recalls, including supplement intake. Polyclonal mitogen phytohemmagluttin (PHA) was the immune function stimulator used. Height and weight were used to calculate body mass index.
STATISTICAL ANALYSES PERFORMED: Descriptive, bivariate correlation, Spearman's rho for nonparametric data, t tests, and stepwise regression with nutrient intakes as independent variables and T-cell proliferation as dependent variables.
RESULTS: Significant positive correlations (P< or =0.05) were found between PHA-induced proliferation and intake of docosahexaenoic acid (DHA), eicosahexaenoic acid (EPA), sodium, and selenium, although intakes of DHA plus EPA were inadequate when compared to recommended intakes. A significant negative correlation with total vitamin A, with many vitamin A levels being above the upper limit of safety. Regression analyses found these nutrients to be variables significant in explaining the variance in PHA (P=0.005).
CONCLUSIONS: Selenium, sodium, DHA, EPA, and vitamin A intake from diet and supplements were associated with PHA-induced proliferative responses. Clients may be counseled to have adequate selenium, EPA, DHA intake, and vitamin A, but avoid excess vitamin A.
Laura Wardwell; Karen Chapman-Novakofski; Susan Herrel; Jeffrey Woods
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  108     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-01-29     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2005-12     Citation Subset:  AIM; IM    
Southern Illinois University School of Law, Carbondale, IL, USA.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Biological Markers
Body Mass Index
Cross-Sectional Studies
Diet / standards*,  statistics & numerical data
Diet Surveys
Dietary Fats, Unsaturated / administration & dosage*
Dietary Supplements / statistics & numerical data,  utilization
Energy Intake / physiology
Geriatric Assessment
Immunity / drug effects,  physiology*
Longitudinal Studies
Mental Recall
Minerals / administration & dosage
Nutritional Physiological Phenomena / physiology*
Nutritional Requirements
Phytohemagglutinins / immunology,  toxicity
Statistics, Nonparametric
Vitamins / administration & dosage
Grant Support
AG-18861/AG/NIA NIH HHS; R01 AG018861-03/AG/NIA NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats, Unsaturated; 0/Minerals; 0/Phytohemagglutinins; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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