| Nutrient-induced inflammation in the intestine. | |
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MedLine Citation:
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PMID: 21587069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To review our current understanding of the relationship between absorption of nutrients and intestinal inflammatory response. RECENT FINDINGS: There is increasing evidence linking gut local inflammatory events with the intake of nutrients. Our recent studies, using the conscious lymph fistula rat model, demonstrate that fat absorption activates the intestinal mucosal mast cells. This is accompanied by a dramatic increase in the lymphatic release of mast cell mediators including histamine, rat mucosal mast cell protease II (RMCPII), as well as the lipid mediator prostaglandin D2 (PGD2). Clinical studies suggest that increased consumption of animal fat may play a role in the pathogenesis of inflammatory bowel disease. This impact of dietary fat may not be restricted to the gut but may extend to the whole body. There is evidence linking a high-fat diet-induced metabolic syndrome, with a low-grade chronic inflammatory state. In this review, we hope to convince the readers that fat absorption can have far reaching physiological and pathophysiological consequences. SUMMARY: Understanding the relationship between nutrient absorption and intestinal inflammation is important. We need a better understanding of the interaction between enterocytes and the intestinal immune cells in nutrient absorption and the gut inflammatory responses. |
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Authors:
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Yong Ji; Yasuhisa Sakata; Patrick Tso |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 14 ISSN: 1473-6519 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-10 Completed Date: 2011-10-06 Revised Date: 2011-12-09 |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 315-21 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amine Oxidase (Copper-Containing)
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metabolism Animals Dietary Fats / adverse effects*, pharmacokinetics Disease Models, Animal Histamine / metabolism Inflammation / pathology* Inflammatory Bowel Diseases / pathology Intestinal Absorption / physiology* Intestines / metabolism* Mast Cells / immunology, metabolism Metabolic Syndrome X / pathology Prostaglandin D2 / metabolism Rats Serine Endopeptidases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK-56863/DK/NIDDK NIH HHS; DK-59360/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 41598-07-6/Prostaglandin D2; 51-45-6/Histamine; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/cytotoxic T lymphocyte-specific serine protease |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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